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10.1016/j.stemcr.2015.04.012 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2015.04.012 C4471835!4471835!26004632     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cell+Reports 2015 ; 4 (6): 984-94 Nephropedia Template TP {{tp|p=26004632|t=2015. Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis |pdf=|usr=}}{{26004632}} gab.com Text Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26004632 #FOAvip Osteoclasts (OCs) originate from the myeloid cell lineage, but the successive steps in their lineage commitment are ill-defined, especially in humans. To clarify OC origin, we sorted cell populations from pediatric bone marrow (BM) by flow cytometry and assessed their differentiation potential in vitro. Within the CD11b?CD34+c-KIT+ BM cell population, OC-differentiation potential was restricted to FLT3+ cells and enriched in an IL3 receptor (R)?high subset that constituted less than 0.5% of total BM. These IL3R?high cells also generated macrophages (M?s) and dendritic cells (DCs) but lacked granulocyte (GR)-differentiation potential, as demonstrated at the clonal level. The IL3R?low subset was re-defined as common progenitor of GR, M?, OC, and DC (GMODP) and gave rise to the IL3R?high subset that was identified as common progenitor of M?, OC, and DC (MODP). Unbiased transcriptome analysis of CD11b?CD34+c-KIT+FLT3+ IL3R?low and IL3R?high subsets corroborated our definitions of the GMODP and MODP and their developmental relationship. Twit Text FOAVip Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26004632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26004632 #FOAvip English Wikipedia <ref>{{Cite pmid|26004632}}</ref> Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis #MMPMID26004632 Xiao Y; Zijl S; Wang L; de Groot D; van Tol M; Lankester A; Borst J Stem Cell Reports 2015[Jun]; 4 (6): 984-94 PMID26004632show ga Osteoclasts (OCs) originate from the myeloid cell lineage, but the successive steps in their lineage commitment are ill-defined, especially in humans. To clarify OC origin, we sorted cell populations from pediatric bone marrow (BM) by flow cytometry and assessed their differentiation potential in vitro. Within the CD11b?CD34+c-KIT+ BM cell population, OC-differentiation potential was restricted to FLT3+ cells and enriched in an IL3 receptor (R)?high subset that constituted less than 0.5% of total BM. These IL3R?high cells also generated macrophages (M?s) and dendritic cells (DCs) but lacked granulocyte (GR)-differentiation potential, as demonstrated at the clonal level. The IL3R?low subset was re-defined as common progenitor of GR, M?, OC, and DC (GMODP) and gave rise to the IL3R?high subset that was identified as common progenitor of M?, OC, and DC (MODP). Unbiased transcriptome analysis of CD11b?CD34+c-KIT+FLT3+ IL3R?low and IL3R?high subsets corroborated our definitions of the GMODP and MODP and their developmental relationship. äIdentification of the Common Origins of Osteoclasts, Macrophages, and (epmc).pdf DeepDyve Pubget Overpricing