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10.1016/j.stemcr.2015.05.003 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2015.05.003 C4471833!4471833!26028528     free     free     free       Stem+Cell+Reports 2015 ; 4 (6): 995-1003 Nephropedia Template TP {{tp|p=26028528|t=2015. Bmi-1 Regulates Extensive Erythroid Self-Renewal |pdf=|usr=}}{{26028528}} gab.com Text Bmi-1 Regulates Extensive Erythroid Self-Renewal JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26028528 #FOAvip Red blood cells (RBCs), responsible for oxygen delivery and carbon dioxide exchange, are essential for our well-being. Alternative RBC sources are needed to meet the increased demand for RBC transfusions projected to occur as our population ages. We previously have discovered that erythroblasts derived from the early mouse embryo can self-renew extensively ex vivo for many months. To better understand the mechanisms regulating extensive erythroid self-renewal, global gene expression data sets from self-renewing and differentiating erythroblasts were analyzed and revealed the differential expression of Bmi-1. Bmi-1 overexpression conferred extensive self-renewal capacity upon adult bone-marrow-derived self-renewing erythroblasts, which normally have limited proliferative potential. Importantly, Bmi-1 transduction did not interfere with the ability of extensively self-renewing erythroblasts (ESREs) to terminally mature either in vitro or in vivo. Bmi-1-induced ESREs can serve to generate in vitro models of erythroid-intrinsic disorders and ultimately may serve as a source of cultured RBCs for transfusion therapy. Twit Text FOAVip Bmi-1 Regulates Extensive Erythroid Self-Renewal ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26028528 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26028528 #FOAvip English Wikipedia <ref>{{Cite pmid|26028528}}</ref> Bmi-1 Regulates Extensive Erythroid Self-Renewal #MMPMID26028528 Kim A; Olsen J; England S; Huang YS; Fegan K; Delgadillo L; McGrath K; Kingsley P; Waugh R; Palis J Stem Cell Reports 2015[Jun]; 4 (6): 995-1003 PMID26028528show ga Red blood cells (RBCs), responsible for oxygen delivery and carbon dioxide exchange, are essential for our well-being. Alternative RBC sources are needed to meet the increased demand for RBC transfusions projected to occur as our population ages. We previously have discovered that erythroblasts derived from the early mouse embryo can self-renew extensively ex vivo for many months. To better understand the mechanisms regulating extensive erythroid self-renewal, global gene expression data sets from self-renewing and differentiating erythroblasts were analyzed and revealed the differential expression of Bmi-1. Bmi-1 overexpression conferred extensive self-renewal capacity upon adult bone-marrow-derived self-renewing erythroblasts, which normally have limited proliferative potential. Importantly, Bmi-1 transduction did not interfere with the ability of extensively self-renewing erythroblasts (ESREs) to terminally mature either in vitro or in vivo. Bmi-1-induced ESREs can serve to generate in vitro models of erythroid-intrinsic disorders and ultimately may serve as a source of cultured RBCs for transfusion therapy. äBmi-1 Regulates Extensive Erythroid Self-Renewal (epmc).pdf DeepDyve Pubget Overpricing