Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.stemcr.2015.04.014 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2015.04.014 C4471826!4471826!26028529     free     free     free       Stem+Cell+Reports 2015 ; 4 (6): 955-60 Nephropedia Template TP {{tp|p=26028529|t=2015. Human Germline: A New Research Frontier |pdf=|usr=}}{{26028529}} gab.com Text Human Germline: A New Research Frontier JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26028529 #FOAvip We recently elucidated the mechanism of human primordial germ cell (hPGC) specification and resetting of the epigenome for totipotency. The regulators of hPGC specification also initiate resetting of the epigenome, leading to a comprehensive erasure of DNA methylation, erasure of imprints and X reactivation in early hPGCs in vivo. These studies reveal differences with the mouse model, which are probably due to differences in the regulation of human pluripotency, and in postimplantation development at gastrulation, which indicates the importance of non-rodent models for investigations. Within the extreme hypomethylated environment of the early human germline are loci that are resistant to DNA demethylation, with subsequent predominant expression in neural cells. These loci provide a model for studies on the mechanism of transgenerational epigenetic inheritance, and their response to environmental factors. Such epigenetic mechanism of inheritance could potentially provide greater phenotypic plasticity, with significant consequences for human development and disease. Twit Text FOAVip Human Germline: A New Research Frontier ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=26028529 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26028529 #FOAvip English Wikipedia <ref>{{Cite pmid|26028529}}</ref> Human Germline: A New Research Frontier #MMPMID26028529 Surani M Stem Cell Reports 2015[Jun]; 4 (6): 955-60 PMID26028529show ga We recently elucidated the mechanism of human primordial germ cell (hPGC) specification and resetting of the epigenome for totipotency. The regulators of hPGC specification also initiate resetting of the epigenome, leading to a comprehensive erasure of DNA methylation, erasure of imprints and X reactivation in early hPGCs in vivo. These studies reveal differences with the mouse model, which are probably due to differences in the regulation of human pluripotency, and in postimplantation development at gastrulation, which indicates the importance of non-rodent models for investigations. Within the extreme hypomethylated environment of the early human germline are loci that are resistant to DNA demethylation, with subsequent predominant expression in neural cells. These loci provide a model for studies on the mechanism of transgenerational epigenetic inheritance, and their response to environmental factors. Such epigenetic mechanism of inheritance could potentially provide greater phenotypic plasticity, with significant consequences for human development and disease. äHuman Germline: A New Research Frontier (epmc).pdf DeepDyve Pubget Overpricing