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10.1016/j.celrep.2014.07.034 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.07.034 C4471814!4471814!25159141     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2014 ; 8 (5): 1308-17 Nephropedia Template TP {{tp|p=25159141|t=2014. IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages |pdf=|usr=}}{{25159141}} gab.com Text IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25159141 #FOAvip Interferon Regulatory Factor 5 (IRF5) plays a major role in setting up an inflammatory macrophage phenotype, but the molecular basis of its transcriptional activity is not fully understood. In this study, we conduct a comprehensive genome-wide analysis of IRF5 recruitment in macrophages stimulated with bacterial lipopolysaccharide and discover that IRF5 binds to regulatory elements of highly transcribed genes. Analysis of protein:DNA microarrays demonstrates that IRF5 recognizes the canonical IRF-binding (interferon-stimulated response element [ISRE]) motif in vitro. However, IRF5 binding in vivo appears to rely on its interactions with other proteins. IRF5 binds to a noncanonical composite PU.1:ISRE motif, and its recruitment is aided by RelA. Global gene expression analysis in macrophages deficient in IRF5 and RelA highlights the direct role of the RelA:IRF5 cistrome in regulation of a subset of key inflammatory genes. We map the RelA:IRF5 interaction domain and suggest that interfering with it would offer selective targeting of macrophage inflammatory activities. Twit Text FOAVip IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25159141 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25159141 #FOAvip English Wikipedia <ref>{{Cite pmid|25159141}}</ref> IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages #MMPMID25159141 Saliba D; Heger A; Eames H; Oikonomopoulos S; Teixeira A; Blazek K; Androulidaki A; Wong D; Goh F; Weiss M; Byrne A; Pasparakis M; Ragoussis J; Udalova I Cell Rep 2014[Sep]; 8 (5): 1308-17 PMID25159141show ga Interferon Regulatory Factor 5 (IRF5) plays a major role in setting up an inflammatory macrophage phenotype, but the molecular basis of its transcriptional activity is not fully understood. In this study, we conduct a comprehensive genome-wide analysis of IRF5 recruitment in macrophages stimulated with bacterial lipopolysaccharide and discover that IRF5 binds to regulatory elements of highly transcribed genes. Analysis of protein:DNA microarrays demonstrates that IRF5 recognizes the canonical IRF-binding (interferon-stimulated response element [ISRE]) motif in vitro. However, IRF5 binding in vivo appears to rely on its interactions with other proteins. IRF5 binds to a noncanonical composite PU.1:ISRE motif, and its recruitment is aided by RelA. Global gene expression analysis in macrophages deficient in IRF5 and RelA highlights the direct role of the RelA:IRF5 cistrome in regulation of a subset of key inflammatory genes. We map the RelA:IRF5 interaction domain and suggest that interfering with it would offer selective targeting of macrophage inflammatory activities. äIRF5:RelA Interaction Targets Inflammatory Genes in Macrophages (epmc).pdf DeepDyve Pubget Overpricing