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10.1016/j.celrep.2014.06.044 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.06.044 C4471680!4471680 !25066128     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25066128 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2014 ; 8 (3 ): 883-96 Nephropedia Template TP {{tp|p=25066128 |t=2014. A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis |pdf=|usr=}}{{25066128 }} gab.com Text A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25066128 #FOAvip Neutrophils contain granules loaded with antimicrobial proteins and are regarded as impermeable organelles that deliver cargo via membrane fusion. However, during the formation of neutrophil extracellular traps (NETs), neutrophil elastase (NE) translocates from the granules to the nucleus via an unknown mechanism that does not involve membrane fusion and requires reactive oxygen species (ROS). Here, we show that the ROS triggers the dissociation of NE from a membrane-associated complex into the cytosol and activates its proteolytic activity in a myeloperoxidase (MPO)-dependent manner. In the cytosol, NE first binds and degrades F-actin to arrest actin dynamics and subsequently translocates to the nucleus. The complex is an example of an oxidative signaling scaffold that enables ROS and antimicrobial proteins to regulate neutrophil responses. Furthermore, granules contain protein machinery that transports and delivers cargo across membranes independently of membrane fusion. Twit Text FOAVip A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25066128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25066128 #FOAvip English Wikipedia <ref>{{Cite pmid|25066128 }}</ref> A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis #MMPMID25066128 Metzler KD ; Goosmann C ; Lubojemska A ; Zychlinsky A ; Papayannopoulos V Cell Rep 2014[Aug]; 8 (3 ): 883-96 PMID25066128 show ga Neutrophils contain granules loaded with antimicrobial proteins and are regarded as impermeable organelles that deliver cargo via membrane fusion. However, during the formation of neutrophil extracellular traps (NETs), neutrophil elastase (NE) translocates from the granules to the nucleus via an unknown mechanism that does not involve membrane fusion and requires reactive oxygen species (ROS). Here, we show that the ROS triggers the dissociation of NE from a membrane-associated complex into the cytosol and activates its proteolytic activity in a myeloperoxidase (MPO)-dependent manner. In the cytosol, NE first binds and degrades F-actin to arrest actin dynamics and subsequently translocates to the nucleus. The complex is an example of an oxidative signaling scaffold that enables ROS and antimicrobial proteins to regulate neutrophil responses. Furthermore, granules contain protein machinery that transports and delivers cargo across membranes independently of membrane fusion. |Actins/*metabolism [MESH] |Active Transport, Cell Nucleus [MESH] |Cell Membrane/metabolism [MESH] |Cell Nucleus/*metabolism [MESH] |Extracellular Traps/*metabolism [MESH] |Humans [MESH] |Leukocyte Elastase/*metabolism [MESH] |Neutrophils/enzymology/*metabolism [MESH] |Peroxidase/*metabolism [MESH] |Protein Binding [MESH] |Proteolysis [MESH]A myeloperoxidase-containing complex regulates neutrophil elastase rel(epmc).pdf DeepDyve Pubget Overpricing