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2015 ; 2015
(ä): 517597
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Fecal Microbiota Transplantation Improves the Quality of Life in Patients with
Inflammatory Bowel Disease
#MMPMID26146498
Wei Y
; Zhu W
; Gong J
; Guo D
; Gu L
; Li N
; Li J
Gastroenterol Res Pract
2015[]; 2015
(ä): 517597
PMID26146498
show ga
Introduction. To determine the effect of fecal microbiota transplantation (FMT)
on quality of life (QoL) in patients with inflammatory bowel disease (IBD).
Methods. Fourteen IBD patients, including 11 Ulcerative colitis (UC) and 3
Crohn's disease (CD), were treated with FMT via colonoscopy or nasojejunal tube
infusion. QoL was measured by IBD Questionnaire (IBDQ). Disease activity and IBDQ
were evaluated at enrollment and four weeks after treatment. Patients' attitude
concerning the treatment was also investigated. Results. One patient was excluded
due to intolerance. All the other patients finished the study well. Mean Mayo
score in UC patients decreased significantly (5.80 ± 1.87 versus 1.50 ± 1.35, P <
0.01). Mean IBDQ scores of both UC and CD patients increased (135.50 ± 27.18
versus 177.30 ± 20.88, P = 0.00063, and 107.33 ± 9.45 versus 149.00 ± 20.07, P =
0.024) four weeks after fecal microbiota transplantation. There was no
correlation between the IBDQ score and Mayo score before and after FMT. Patients
refused to take FMT as treatment repeatedly in a short time. Conlusions. Fecal
microbiota transplantation improves quality of life significantly in patients
with inflammatory bowel disease.