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2015 ; 4
(1
): 1-15
Nephropedia Template TP
gab.com Text
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English Wikipedia
5% Lidocaine Medicated Plaster for the Treatment of Postherpetic Neuralgia: A
Review of the Clinical Safety and Tolerability
#MMPMID25896574
Navez ML
; Monella C
; Bösl I
; Sommer D
; Delorme C
Pain Ther
2015[Jun]; 4
(1
): 1-15
PMID25896574
show ga
Postherpetic neuralgia (PHN) is a common, very painful, and often long-lasting
complication of herpes zoster which is frequently underdiagnosed and
undertreated. It mainly affects the elderly, many of whom are already treated for
comorbidities with a variety of systemic medications and are thus at high risk of
drug-drug interactions. An efficacious and safe treatment with a low interaction
potential is therefore of high importance. This review focuses on the safety and
tolerability of the 5% lidocaine medicated plaster, a topical analgesic indicated
for the treatment of PHN. The available literature (up to June 2014) was searched
for publications containing safety data regarding the use of the 5% lidocaine
medicated plaster in PHN treatment; unpublished clinical safety data were also
included in this review. The 5% lidocaine medicated plaster demonstrated good
short- and long-term tolerability with low systemic uptake (3 ± 2%) and minimal
risk for systemic adverse drug reactions (ADRs). ADRs related to topical
lidocaine treatment were mainly application site reactions of mild to moderate
intensity. The treatment discontinuation rate was generally below 5% of patients.
In one trial, the 5% lidocaine medicated plaster was better tolerated than
systemic treatment with pregabalin. The 5% lidocaine medicated plaster provides a
safe alternative to systemic medications for PHN treatment, including long-term
pain treatment.
free
free
free
