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10.1007/s40122-014-0030-6

http://scihub22266oqcxt.onion/10.1007/s40122-014-0030-6
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suck abstract from ncbi


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pmid25558866      Pain+Ther 2015 ; 4 (1): 107-17
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  • Lasting Prolonged-Release Tapentadol for Moderate/Severe Non-Cancer Musculoskeletal Chronic Pain #MMPMID25558866
  • Samolsky Dekel BG; Ghedini S; Gori A; Vasarri A; Di Nino G; Melotti RM
  • Pain Ther 2015[Jun]; 4 (1): 107-17 PMID25558866show ga
  • Introduction: Despite opioids? recognized role in the treatment of moderate/severe musculoskeletal chronic pain, their long-term benefits need investigation. We explored the lasting analgesic efficacy, tolerability, influence on life quality, and chronicity stage of the novel prolonged release (PR) opioid, tapentadol, in 30 outpatients. Methods: We evaluated patients? pain intensity and relief (Numerical Rating Scale; NRS), adverse effects, sleep quality, treatment satisfaction, health status (12-questions Health-Survey; SF-12), chronicity stage (Italian Mainz Pain-Staging System; I-MPSS) at 10, 30, 60, and 90 days after tapentadol prescription. Results: At follow-ups, the investigated outcomes showed an overall statistically significant (Wilcoxon signed-rank test) improvement and remained stable over time, as did the health status and chronicity stage. Adverse effects were limited, transitory, and tolerable. Conclusions: Twelve weeks of PR tapentadol in outpatients with moderate/severe chronic musculoskeletal pain showed satisfactory analgesic efficacy and tolerability, and had a positive influence on life quality and chronicity stage. The results are robust enough to warrant a subsequent study with a larger sample and a longer observation period.
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