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10.1117/12.2082739

http://scihub22266oqcxt.onion/10.1117/12.2082739
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C4470574!4470574!26097280
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suck abstract from ncbi


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pmid26097280      Proc+SPIE+Int+Soc+Opt+Eng 2015 ; 9412 (ä): ä
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  • Initial results from a prototype whole-body photon-counting computed tomography system #MMPMID26097280
  • Yu Z; Leng S; Jorgensen SM; Li Z; Gutjahr R; Chen B; Duan X; Halaweish AF; Yu L; Ritman EL; McCollough CH
  • Proc SPIE Int Soc Opt Eng 2015[]; 9412 (ä): ä PMID26097280show ga
  • X-ray computed tomography (CT) with energy-discriminating capabilities presents exciting opportunities for increased dose efficiency and improved material decomposition analyses. However, due to constraints imposed by the inability of photon-counting detectors (PCD) to respond accurately at high photon flux, to date there has been no clinical application of PCD-CT. Recently, our lab installed a research prototype system consisting of two x-ray sources and two corresponding detectors, one using an energy-integrating detector (EID) and the other using a PCD. In this work, we report the first third-party evaluation of this prototype CT system using both phantoms and a cadaver head. The phantom studies demonstrated several promising characteristics of the PCD sub-system, including improved longitudinal spatial resolution and reduced beam hardening artifacts, relative to the EID sub-system. More importantly, we found that the PCD sub-system offers excellent pulse pileup control in cases of x-ray flux up to 550 mA at 140 kV, which corresponds to approximately 2.5×1011 photons per cm2 per second. In an anthropomorphic phantom and a cadaver head, the PCD sub-system provided image quality comparable to the EID sub-system for the same dose level. Our results demonstrate the potential of the prototype system to produce clinically-acceptable images in vivo.
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