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10.1097/RLI.0b013e3181ec9b02 http://scihub22266oqcxt.onion/10.1097/RLI.0b013e3181ec9b02 C4470562!4470562!20829708     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Invest+Radiol 2010 ; 45 (12): 819-22 Nephropedia Template TP {{tp|p=20829708|t=2010. Evaluation of Renal Hypoxia in Diabetic Mice by BOLD MRI |pdf=|usr=}}{{20829708}} gab.com Text Evaluation of Renal Hypoxia in Diabetic Mice by BOLD MRI JO: Invest Radiol http://www.kidney.de/pget.php?&tw=1&pmid=20829708 #FOAvip Objective: Renal hypoxia has been proposed to be a pathophysiologic feature of diabetic kidney disease but it has been difficult to demonstrate in vivo, particularly in mouse models of diabetes. The objective of this work was to examine the sensitivity of blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) to assess renal oxygenation in vivo in a mouse model of diabetic kidney disease, the db/db mice. Research Design and Methods: Kidney BOLD MRI studies were performed on a 3.0 T scanner using multiple gradient echo sequence with a custom-designed surface coil to acquire T2*-weighted images. Studies were performed in 10-week-old db/db mice (n = 7) and db/m controls (n = 6). Results: R2* is a measure of the tissue deoxyhemoglobin concentration and higher values of R2* are associated with hypoxia. The db/db mice had higher medullary (43.1 ± 5.1 s?1 vs. 32.3 ± 3.7 s?1, P = 0.001) and cortical R2* (31.7 ± 3.1 s?1 vs. 27.1 ± 4.1 s?1, P = 0.04) values. Using pimonidazole staining as a marker of kidney hypoxia, in kidney sections from 10-week-old db/db mice neither cortex nor medulla had significant differences as compared with 10-week-old db/m mice (cortex: db/db 2.14 ± 0.05 vs. db/m 2.02 ± 0.28, medulla: db/db 2.81 ± 0.08 vs. db/m 2.6 ± 0.08). The db/db mice demonstrated further increased cortical and medullary hypoxia when scanned again at 15 weeks of age. Conclusions: The report shows that renal BOLD MRI is a sensitive method for the in vivo evaluation of renal hypoxia in a mouse model of diabetic kidney disease where progressive renal hypoxia can be documented over time. BOLD MRI may be useful to monitor therapeutic interventions that may improve tissue hypoxia in the diabetic kidney. Twit Text FOAVip Evaluation of Renal Hypoxia in Diabetic Mice by BOLD MRI ????Invest Radiol http://www.kidney.de/pget.php?&tw=1&pmid=20829708 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20829708 #FOAvip English Wikipedia <ref>{{Cite pmid|20829708}}</ref> Evaluation of Renal Hypoxia in Diabetic Mice by BOLD MRI #MMPMID20829708 Prasad P; Li LP; Halter S; Cabray J; Ye M; Batlle D Invest Radiol 2010[Dec]; 45 (12): 819-22 PMID20829708show ga Objective: Renal hypoxia has been proposed to be a pathophysiologic feature of diabetic kidney disease but it has been difficult to demonstrate in vivo, particularly in mouse models of diabetes. The objective of this work was to examine the sensitivity of blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) to assess renal oxygenation in vivo in a mouse model of diabetic kidney disease, the db/db mice. Research Design and Methods: Kidney BOLD MRI studies were performed on a 3.0 T scanner using multiple gradient echo sequence with a custom-designed surface coil to acquire T2*-weighted images. Studies were performed in 10-week-old db/db mice (n = 7) and db/m controls (n = 6). Results: R2* is a measure of the tissue deoxyhemoglobin concentration and higher values of R2* are associated with hypoxia. The db/db mice had higher medullary (43.1 ± 5.1 s?1 vs. 32.3 ± 3.7 s?1, P = 0.001) and cortical R2* (31.7 ± 3.1 s?1 vs. 27.1 ± 4.1 s?1, P = 0.04) values. Using pimonidazole staining as a marker of kidney hypoxia, in kidney sections from 10-week-old db/db mice neither cortex nor medulla had significant differences as compared with 10-week-old db/m mice (cortex: db/db 2.14 ± 0.05 vs. db/m 2.02 ± 0.28, medulla: db/db 2.81 ± 0.08 vs. db/m 2.6 ± 0.08). The db/db mice demonstrated further increased cortical and medullary hypoxia when scanned again at 15 weeks of age. Conclusions: The report shows that renal BOLD MRI is a sensitive method for the in vivo evaluation of renal hypoxia in a mouse model of diabetic kidney disease where progressive renal hypoxia can be documented over time. BOLD MRI may be useful to monitor therapeutic interventions that may improve tissue hypoxia in the diabetic kidney. äEvaluation of Renal Hypoxia in Diabetic Mice by BOLD MRI (epmc).pdf DeepDyve Pubget Overpricing