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10.1007/s10549-012-2056-y

http://scihub22266oqcxt.onion/10.1007/s10549-012-2056-y
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suck abstract from ncbi


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pmid22527103
      Breast+Cancer+Res+Treat 2012 ; 134 (3 ): 1209-20
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  • Risk factors for uncommon histologic subtypes of breast cancer using centralized pathology review in the Breast Cancer Family Registry #MMPMID22527103
  • Work ME ; Andrulis IL ; John EM ; Hopper JL ; Liao Y ; Zhang FF ; Knight JA ; West DW ; Milne RL ; Giles GG ; Longacre TA ; O'Malley F ; Mulligan AM ; Southey MC ; Hibshoosh H ; Terry MB
  • Breast Cancer Res Treat 2012[Aug]; 134 (3 ): 1209-20 PMID22527103 show ga
  • Epidemiologic studies of histologic types of breast cancer including mucinous, medullary, and tubular carcinomas have primarily relied on International Classification of Diseases-Oncology (ICD-O) codes assigned by local pathologists to define histology. Using data from the Breast Cancer Family Registry (BCFR), we compared histologic agreement between centralized BCFR pathology review and ICD-O codes available from local tumor registries among 3,260 breast cancer cases. Agreement was low to moderate for less common histologies; for example, only 55 and 26 % of cases classified as mucinous and medullary, respectively, by centralized review were similarly classified using ICD-O coding. We then evaluated risk factors for each histologic subtype by comparing each histologic case group defined by centralized review with a common set of 2,997 population-based controls using polytomous logistic regression. Parity [odds ratio (OR) = 0.4, 95 % confidence interval (95 % CI): 0.2-0.9, for parous vs. nulliparous], age at menarche (OR = 0.5, 95 % CI: 0.3-0.9, for age ?13 vs. ?11), and use of oral contraceptives (OCs) (OR = 0.5, 95 % CI: 0.2-0.8, OC use >5 years vs. never) were associated with mucinous carcinoma (N = 92 cases). Body mass index (BMI) (OR = 1.05, 95 % CI: 1.0-1.1, per unit of BMI) and high parity (OR = 2.6, 95 % CI: 1.1-6.0 for ?3 live births vs. nulliparous) were associated with medullary carcinoma (N = 90 cases). We did not find any associations between breast cancer risk factors and tubular carcinoma (N = 86 cases). Relative risk estimates from analyses using ICD-O classifications of histology, rather than centralized review, resulted in attenuated, and/or more imprecise, associations. These findings suggest risk factor heterogeneity across breast cancer tumor histologies, and demonstrate the value of centralized pathology review for classifying rarer tumor types.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Breast Neoplasms/classification/*epidemiology/*pathology [MESH]
  • |Case-Control Studies [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Middle Aged [MESH]
  • |Registries [MESH]
  • |Risk Factors [MESH]


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