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2012 ; 134
(3
): 1209-20
Nephropedia Template TP
gab.com Text
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English Wikipedia
Risk factors for uncommon histologic subtypes of breast cancer using centralized
pathology review in the Breast Cancer Family Registry
#MMPMID22527103
Work ME
; Andrulis IL
; John EM
; Hopper JL
; Liao Y
; Zhang FF
; Knight JA
; West DW
; Milne RL
; Giles GG
; Longacre TA
; O'Malley F
; Mulligan AM
; Southey MC
; Hibshoosh H
; Terry MB
Breast Cancer Res Treat
2012[Aug]; 134
(3
): 1209-20
PMID22527103
show ga
Epidemiologic studies of histologic types of breast cancer including mucinous,
medullary, and tubular carcinomas have primarily relied on International
Classification of Diseases-Oncology (ICD-O) codes assigned by local pathologists
to define histology. Using data from the Breast Cancer Family Registry (BCFR), we
compared histologic agreement between centralized BCFR pathology review and ICD-O
codes available from local tumor registries among 3,260 breast cancer cases.
Agreement was low to moderate for less common histologies; for example, only 55
and 26 % of cases classified as mucinous and medullary, respectively, by
centralized review were similarly classified using ICD-O coding. We then
evaluated risk factors for each histologic subtype by comparing each histologic
case group defined by centralized review with a common set of 2,997
population-based controls using polytomous logistic regression. Parity [odds
ratio (OR) = 0.4, 95 % confidence interval (95 % CI): 0.2-0.9, for parous vs.
nulliparous], age at menarche (OR = 0.5, 95 % CI: 0.3-0.9, for age ?13 vs. ?11),
and use of oral contraceptives (OCs) (OR = 0.5, 95 % CI: 0.2-0.8, OC use >5 years
vs. never) were associated with mucinous carcinoma (N = 92 cases). Body mass
index (BMI) (OR = 1.05, 95 % CI: 1.0-1.1, per unit of BMI) and high parity (OR =
2.6, 95 % CI: 1.1-6.0 for ?3 live births vs. nulliparous) were associated with
medullary carcinoma (N = 90 cases). We did not find any associations between
breast cancer risk factors and tubular carcinoma (N = 86 cases). Relative risk
estimates from analyses using ICD-O classifications of histology, rather than
centralized review, resulted in attenuated, and/or more imprecise, associations.
These findings suggest risk factor heterogeneity across breast cancer tumor
histologies, and demonstrate the value of centralized pathology review for
classifying rarer tumor types.