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10.3390/jcm4010172 http://scihub22266oqcxt.onion/10.3390/jcm4010172 C4470247!4470247!26237026     free     free     free       J+Clin+Med 2015 ; 4 (1): 172-92 Nephropedia Template TP {{tp|p=26237026|t=2015. NLRP3 Inflammasome and Pathobiology in AMD |pdf=|usr=}}{{26237026}} gab.com Text NLRP3 Inflammasome and Pathobiology in AMD JO: J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=26237026 #FOAvip Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is characterized by a progressive loss of photoreceptors in the macula due to damage to the retinal pigment epithelium (RPE). Clinically, it is manifested by drusen deposition between the RPE and underlying choroid and accumulation of lipofuscin in the RPE. End-stage disease is characterized by geographic atrophy (dry AMD) or choroidal neovascularization (wet AMD). The NLRP3 inflammasome has recently been implicated in the disease pathology. Here we review the current knowledge on the involvement of this multiprotein complex and its effector cytokines interleukin-1? (IL-1?) and IL-18 in AMD progression. We also describe cell death mechanisms that have been proposed to underlie RPE degeneration in AMD and discuss the role of autophagy in the regulation of disease progression. Twit Text FOAVip NLRP3 Inflammasome and Pathobiology in AMD ????J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=26237026 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26237026 #FOAvip English Wikipedia <ref>{{Cite pmid|26237026}}</ref> NLRP3 Inflammasome and Pathobiology in AMD #MMPMID26237026 Celkova L; Doyle SL; Campbell M J Clin Med 2015[Jan]; 4 (1): 172-92 PMID26237026show ga Age-related macular degeneration (AMD) is the leading cause of central vision loss and blindness in the elderly. It is characterized by a progressive loss of photoreceptors in the macula due to damage to the retinal pigment epithelium (RPE). Clinically, it is manifested by drusen deposition between the RPE and underlying choroid and accumulation of lipofuscin in the RPE. End-stage disease is characterized by geographic atrophy (dry AMD) or choroidal neovascularization (wet AMD). The NLRP3 inflammasome has recently been implicated in the disease pathology. Here we review the current knowledge on the involvement of this multiprotein complex and its effector cytokines interleukin-1? (IL-1?) and IL-18 in AMD progression. We also describe cell death mechanisms that have been proposed to underlie RPE degeneration in AMD and discuss the role of autophagy in the regulation of disease progression. äNLRP3 Inflammasome and Pathobiology in AMD (epmc).pdf DeepDyve Pubget Overpricing