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10.3390/jcm2030136 http://scihub22266oqcxt.onion/10.3390/jcm2030136 C4470233!4470233!26237067     free     free     free       J+Clin+Med 2013 ; 2 (3): 136-50 Nephropedia Template TP {{tp|p=26237067|t=2013. Mechanisms of Metastatic Tumor Dormancy |pdf=|usr=}}{{26237067}} gab.com Text Mechanisms of Metastatic Tumor Dormancy JO: J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=26237067 #FOAvip Tumor metastasis can occur years after an apparent cure due to a phenomenon known as metastatic tumor dormancy; in which tumor masses or individual tumor cells are growth restricted for extended periods of time. This period of dormancy is induced and maintained by several mechanisms, including: (1) Tumor microenvironment factors such as cytokine expression, immunosurveillance and angiogenesis; (2) Metastasis suppressor gene activity; and (3) Cancer therapeutics. Disseminated tumor cells (DTC) are the key cells that result in dormant tumors. However, many challenges exist towards isolating DTCs for mechanistic studies. The main DTC that may represent the dormant cell is the cancer stem cells (CSC) as they have a slow proliferation rate. In addition to limited knowledge regarding induction of tumor dormancy, there are large gaps in knowledge regarding how tumors escape from dormancy. Emerging research into cancer stem cells, immunotherapy, and metastasis suppressor genes, may lead to new approaches for targeted anti-metastatic therapy to prevent dormancy escape. Overall, an enhanced understanding of tumor dormancy is critical for better targeting and treatment of patients to prevent cancer recurrence. Twit Text FOAVip Mechanisms of Metastatic Tumor Dormancy ????J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=26237067 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26237067 #FOAvip English Wikipedia <ref>{{Cite pmid|26237067}}</ref> Mechanisms of Metastatic Tumor Dormancy #MMPMID26237067 Osisami M; Keller ET J Clin Med 2013[Sep]; 2 (3): 136-50 PMID26237067show ga Tumor metastasis can occur years after an apparent cure due to a phenomenon known as metastatic tumor dormancy; in which tumor masses or individual tumor cells are growth restricted for extended periods of time. This period of dormancy is induced and maintained by several mechanisms, including: (1) Tumor microenvironment factors such as cytokine expression, immunosurveillance and angiogenesis; (2) Metastasis suppressor gene activity; and (3) Cancer therapeutics. Disseminated tumor cells (DTC) are the key cells that result in dormant tumors. However, many challenges exist towards isolating DTCs for mechanistic studies. The main DTC that may represent the dormant cell is the cancer stem cells (CSC) as they have a slow proliferation rate. In addition to limited knowledge regarding induction of tumor dormancy, there are large gaps in knowledge regarding how tumors escape from dormancy. Emerging research into cancer stem cells, immunotherapy, and metastasis suppressor genes, may lead to new approaches for targeted anti-metastatic therapy to prevent dormancy escape. Overall, an enhanced understanding of tumor dormancy is critical for better targeting and treatment of patients to prevent cancer recurrence. äMechanisms of Metastatic Tumor Dormancy (epmc).pdf DeepDyve Pubget Overpricing