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10.3390/jcm3041146 http://scihub22266oqcxt.onion/10.3390/jcm3041146 C4470175!4470175!26237596     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26237596&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Med 2014 ; 3 (4): 1146-62 Nephropedia Template TP {{tp|p=26237596|t=2014. Comparing ESC and iPSC?Based Models for Human Genetic Disorders |pdf=|usr=}}{{26237596}} gab.com Text Comparing ESC and iPSC Based Models for Human Genetic Disorders JO: J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=26237596 #FOAvip Traditionally, human disorders were studied using animal models or somatic cells taken from patients. Such studies enabled the analysis of the molecular mechanisms of numerous disorders, and led to the discovery of new treatments. Yet, these systems are limited or even irrelevant in modeling multiple genetic diseases. The isolation of human embryonic stem cells (ESCs) from diseased blastocysts, the derivation of induced pluripotent stem cells (iPSCs) from patients? somatic cells, and the new technologies for genome editing of pluripotent stem cells have opened a new window of opportunities in the field of disease modeling, and enabled studying diseases that couldn?t be modeled in the past. Importantly, despite the high similarity between ESCs and iPSCs, there are several fundamental differences between these cells, which have important implications regarding disease modeling. In this review we compare ESC-based models to iPSC-based models, and highlight the advantages and disadvantages of each system. We further suggest a roadmap for how to choose the optimal strategy to model each specific disorder. Twit Text FOAVip Comparing ESC and iPSC Based Models for Human Genetic Disorders ????J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=26237596 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26237596 #FOAvip English Wikipedia <ref>{{Cite pmid|26237596}}</ref> Comparing ESC and iPSC?Based Models for Human Genetic Disorders #MMPMID26237596 Halevy T; Urbach A J Clin Med 2014[Dec]; 3 (4): 1146-62 PMID26237596show ga Traditionally, human disorders were studied using animal models or somatic cells taken from patients. Such studies enabled the analysis of the molecular mechanisms of numerous disorders, and led to the discovery of new treatments. Yet, these systems are limited or even irrelevant in modeling multiple genetic diseases. The isolation of human embryonic stem cells (ESCs) from diseased blastocysts, the derivation of induced pluripotent stem cells (iPSCs) from patients? somatic cells, and the new technologies for genome editing of pluripotent stem cells have opened a new window of opportunities in the field of disease modeling, and enabled studying diseases that couldn?t be modeled in the past. Importantly, despite the high similarity between ESCs and iPSCs, there are several fundamental differences between these cells, which have important implications regarding disease modeling. In this review we compare ESC-based models to iPSC-based models, and highlight the advantages and disadvantages of each system. We further suggest a roadmap for how to choose the optimal strategy to model each specific disorder. äComparing ESC and iPSC?Based Models for Human Genetic Disorders (epmc).pdf DeepDyve Pubget Overpricing