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10.1186/s40246-015-0029-z http://scihub22266oqcxt.onion/10.1186/s40246-015-0029-z C4469999!4469999!26054645     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hum+Genomics 2015 ; 9 (1): ä Nephropedia Template TP {{tp|p=26054645|t=2015. Complement regulator CD46: genetic variants and disease associations |pdf=|usr=}}{{26054645}} gab.com Text Complement regulator CD46: genetic variants and disease associations JO: Hum Genomics http://www.kidney.de/pget.php?&tw=1&pmid=26054645 #FOAvip Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement. This type-I membrane glycoprotein serves as a cofactor for the serine protease factor I to mediate inactivation of C3b and C4b deposited on host cells. More than 60 disease-associated mutations in MCP have now been identified. The majority of the mutations are linked to a rare thrombotic microangiopathic-based disease, atypical hemolytic uremic syndrome (aHUS), but new putative links to systemic lupus erythematosus, glomerulonephritis, and pregnancy-related disorders among others have also been identified. This review summarizes our current knowledge of disease-associated mutations in this complement inhibitor. Twit Text FOAVip Complement regulator CD46: genetic variants and disease associations ????Hum Genomics http://www.kidney.de/pget.php?&tw=1&pmid=26054645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26054645 #FOAvip English Wikipedia <ref>{{Cite pmid|26054645}}</ref> Complement regulator CD46: genetic variants and disease associations #MMPMID26054645 Liszewski MK; Atkinson JP Hum Genomics 2015[]; 9 (1): ä PMID26054645show ga Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement. This type-I membrane glycoprotein serves as a cofactor for the serine protease factor I to mediate inactivation of C3b and C4b deposited on host cells. More than 60 disease-associated mutations in MCP have now been identified. The majority of the mutations are linked to a rare thrombotic microangiopathic-based disease, atypical hemolytic uremic syndrome (aHUS), but new putative links to systemic lupus erythematosus, glomerulonephritis, and pregnancy-related disorders among others have also been identified. This review summarizes our current knowledge of disease-associated mutations in this complement inhibitor. äComplement regulator CD46: genetic variants and disease associations (epmc).pdf DeepDyve Pubget Overpricing