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10.1152/ajprenal.00030.2015 http://scihub22266oqcxt.onion/10.1152/ajprenal.00030.2015 C4469890!4469890!25877507     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2015 ; 308 (12): F1317-23 Nephropedia Template TP {{tp|p=25877507|t=2015. Tubular cross talk in acute kidney injury: a story of sense and sensibility |pdf=|usr=}}{{25877507}} gab.com Text Tubular cross talk in acute kidney injury: a story of sense and sensibility JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25877507 #FOAvip The mammalian kidney is an organ composed of numerous functional units or nephrons. Beyond the filtering glomerulus of each nephron, various tubular segments with distinct populations of epithelial cells sequentially span the kidney from cortex to medulla. The highly organized folding of the tubules results in a spatial distribution that allows intimate contact between various tubular subsegments. This unique arrangement can promote a newly recognized type of horizontal epithelial-to-epithelial cross talk. In this review, we discuss the importance of this tubular cross talk in shaping the response of the kidney to acute injury in a sense and sensibility model. We propose that injury-resistant tubules such as S1 proximal segments and thick ascending limbs (TAL) can act as ?sensors? and thus modulate the responsiveness or ?sensibility? of the S2-S3 proximal segments to injury. We also discuss new findings that highlight the importance of tubular cross talk in regulating homeostasis and inflammation not only in the kidney, but also systemically. Twit Text FOAVip Tubular cross talk in acute kidney injury: a story of sense and sensibility ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25877507 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25877507 #FOAvip English Wikipedia <ref>{{Cite pmid|25877507}}</ref> Tubular cross talk in acute kidney injury: a story of sense and sensibility #MMPMID25877507 El-Achkar TM; Dagher PC Am J Physiol Renal Physiol 2015[Jun]; 308 (12): F1317-23 PMID25877507show ga The mammalian kidney is an organ composed of numerous functional units or nephrons. Beyond the filtering glomerulus of each nephron, various tubular segments with distinct populations of epithelial cells sequentially span the kidney from cortex to medulla. The highly organized folding of the tubules results in a spatial distribution that allows intimate contact between various tubular subsegments. This unique arrangement can promote a newly recognized type of horizontal epithelial-to-epithelial cross talk. In this review, we discuss the importance of this tubular cross talk in shaping the response of the kidney to acute injury in a sense and sensibility model. We propose that injury-resistant tubules such as S1 proximal segments and thick ascending limbs (TAL) can act as ?sensors? and thus modulate the responsiveness or ?sensibility? of the S2-S3 proximal segments to injury. We also discuss new findings that highlight the importance of tubular cross talk in regulating homeostasis and inflammation not only in the kidney, but also systemically. äTubular cross talk in acute kidney injury: a story of sense and sensib(epmc).pdf DeepDyve Pubget Overpricing