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10.1152/ajprenal.00410.2014 http://scihub22266oqcxt.onion/10.1152/ajprenal.00410.2014 C4469887!4469887 !25834070     free     free     free       Am+J+Physiol+Renal+Physiol 2015 ; 308 (12 ): F1335-42 Nephropedia Template TP {{tp|p=25834070 |t=2015. Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd-skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis |pdf=|usr=}}{{25834070 }} gab.com Text Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd-skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25834070 #FOAvip Many genes, including odd-skipped related 1 (Osr1), are involved in regulation of mammalian kidney development. We describe here a new recessive mutation (kidney adysplasia and variable hydronephrosis, kavh) in the mouse that leads to downregulation of Osr1 transcript, causing several kidney defects: agenesis, hypoplasia, and hydronephrosis with variable age of onset. The mutation is closely associated with a reciprocal translocation, T(12;17)4Rk, whose Chromosome 12 breakpoint is upstream from Osr1. The kavh/kavh mutant provides a model to study kidney development and test therapies for hydronephrosis. Twit Text FOAVip Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd-skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25834070 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25834070 #FOAvip English Wikipedia <ref>{{Cite pmid|25834070 }}</ref> Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd-skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis #MMPMID25834070 Davisson MT ; Cook SA ; Akeson EC ; Liu D ; Heffner C ; Gudis P ; Fairfield H ; Murray SA Am J Physiol Renal Physiol 2015[Jun]; 308 (12 ): F1335-42 PMID25834070 show ga Many genes, including odd-skipped related 1 (Osr1), are involved in regulation of mammalian kidney development. We describe here a new recessive mutation (kidney adysplasia and variable hydronephrosis, kavh) in the mouse that leads to downregulation of Osr1 transcript, causing several kidney defects: agenesis, hypoplasia, and hydronephrosis with variable age of onset. The mutation is closely associated with a reciprocal translocation, T(12;17)4Rk, whose Chromosome 12 breakpoint is upstream from Osr1. The kavh/kavh mutant provides a model to study kidney development and test therapies for hydronephrosis. |Animals [MESH] |Gene Expression Regulation, Developmental/*genetics [MESH] |Hydronephrosis/*etiology/genetics [MESH] |Kidney/*abnormalities/metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mutation/*genetics [MESH] |Organogenesis/genetics/*physiology [MESH] |Transcription Factors/*genetics/metabolism [MESH]Kidney adysplasia and variable hydronephrosis, a new mutation affectin(epmc).pdf DeepDyve Pubget Overpricing