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10.1111/cei.12622 http://scihub22266oqcxt.onion/10.1111/cei.12622 C4469151!4469151!25753381     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2015 ; 181 (1): 1-18 Nephropedia Template TP {{tp|p=25753381|t=2015. The T cell antigen receptor: the Swiss army knife of the immune system |pdf=|usr=}}{{25753381}} gab.com Text The T cell antigen receptor: the Swiss army knife of the immune system JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25753381 #FOAvip The mammalian T cell receptor (TCR) orchestrates immunity by responding to many billions of different ligands that it has never encountered before and cannot adapt to at the protein sequence level. This remarkable receptor exists in two main heterodimeric isoforms: ?? TCR and ?? TCR. The ?? TCR is expressed on the majority of peripheral T cells. Most ?? T cells recognize peptides, derived from degraded proteins, presented at the cell surface in molecular cradles called major histocompatibility complex (MHC) molecules. Recent reports have described other ?? T cell subsets. These ?unconventional? T cells bear TCRs that are capable of recognizing lipid ligands presented in the context of the MHC-like CD1 protein family or bacterial metabolites bound to the MHC-related protein 1 (MR1). ?? T cells constitute a minority of the T cell pool in human blood, but can represent up to half of total T cells in tissues such as the gut and skin. The identity of the preferred ligands for ?? T cells remains obscure, but it is now known that this receptor can also functionally engage CD1-lipid, or immunoglobulin (Ig) superfamily proteins called butyrophilins in the presence of pyrophosphate intermediates of bacterial lipid biosynthesis. Interactions between TCRs and these ligands allow the host to discriminate between self and non-self and co-ordinate an attack on the latter. Here, we describe how cells of the T lymphocyte lineage and their antigen receptors are generated and discuss the various modes of antigen recognition by these extraordinarily versatile receptors. Twit Text FOAVip The T cell antigen receptor: the Swiss army knife of the immune system ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25753381 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25753381 #FOAvip English Wikipedia <ref>{{Cite pmid|25753381}}</ref> The T cell antigen receptor: the Swiss army knife of the immune system #MMPMID25753381 Attaf M; Legut M; Cole DK; Sewell AK Clin Exp Immunol 2015[Jul]; 181 (1): 1-18 PMID25753381show ga The mammalian T cell receptor (TCR) orchestrates immunity by responding to many billions of different ligands that it has never encountered before and cannot adapt to at the protein sequence level. This remarkable receptor exists in two main heterodimeric isoforms: ?? TCR and ?? TCR. The ?? TCR is expressed on the majority of peripheral T cells. Most ?? T cells recognize peptides, derived from degraded proteins, presented at the cell surface in molecular cradles called major histocompatibility complex (MHC) molecules. Recent reports have described other ?? T cell subsets. These ?unconventional? T cells bear TCRs that are capable of recognizing lipid ligands presented in the context of the MHC-like CD1 protein family or bacterial metabolites bound to the MHC-related protein 1 (MR1). ?? T cells constitute a minority of the T cell pool in human blood, but can represent up to half of total T cells in tissues such as the gut and skin. The identity of the preferred ligands for ?? T cells remains obscure, but it is now known that this receptor can also functionally engage CD1-lipid, or immunoglobulin (Ig) superfamily proteins called butyrophilins in the presence of pyrophosphate intermediates of bacterial lipid biosynthesis. Interactions between TCRs and these ligands allow the host to discriminate between self and non-self and co-ordinate an attack on the latter. Here, we describe how cells of the T lymphocyte lineage and their antigen receptors are generated and discuss the various modes of antigen recognition by these extraordinarily versatile receptors. äThe T cell antigen receptor: the Swiss army knife of the immune system(epmc).pdf DeepDyve Pubget Overpricing