Acinar Cell Carcinoma of the Pancreas: Overview of Clinicopathologic Features and
Insights into the Molecular Pathology
#MMPMID26137463
La Rosa S
; Sessa F
; Capella C
Front Med (Lausanne)
2015[]; 2
(?): 41
PMID26137463
show ga
Acinar cell carcinomas (ACCs) of the pancreas are rare pancreatic neoplasms
accounting for about 1-2% of pancreatic tumors in adults and about 15% in
pediatric subjects. They show different clinical symptoms at presentation,
different morphological features, different outcomes, and different molecular
alterations. This heterogeneous clinicopathological spectrum may give rise to
difficulties in the clinical and pathological diagnosis with consequential
therapeutic and prognostic implications. The molecular mechanisms involved in the
onset and progression of ACCs are still not completely understood, although in
recent years, several attempts have been made to clarify the molecular mechanisms
involved in ACC biology. In this paper, we will review the main
clinicopathological and molecular features of pancreatic ACCs of both adult and
pediatric subjects to give the reader a comprehensive overview of this rare tumor
type.