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Combination of PAPPA, fhCG?, AFP, PlGF, sTNFR1, and Maternal Characteristics in
Prediction of Early-onset Preeclampsia
#MMPMID26106266
Yliniemi A
; Makikallio K
; Korpimaki T
; Kouru H
; Marttala J
; Ryynanen M
Clin Med Insights Reprod Health
2015[]; 9
(?): 13-20
PMID26106266
show ga
OBJECTIVE: To evaluate the efficacy of first-trimester
markers-pregnancy-associated plasma protein A (PAPPA), free human chorionic
gonadotropin ? (fhCG?), alpha-fetoprotein (AFP), placental growth factor (PlGF),
and soluble tumor necrosis factor receptor-1 (sTNFR1) together with maternal
characteristics (MC) for prediction of early-onset preeclampsia (EOPE). METHODS:
During 2005-2010, the abovementioned biomarkers were analyzed with logistic
regression analysis in 64 EOPE and 752 control subjects to determine whether
these biomarkers separately and in combination with MC would predict development
of EOPE. RESULTS: PAPPA, fhCG?, and PlGF levels were lower, whereas AFP and
sTNFR1 levels were higher in mothers with EOPE compared to controls. The
combination of all markers with MC (age, weight, and smoking status) detected 48%
of the mothers with EOPE, with a 10% false-positive rate (FPR). CONCLUSIONS:
First-trimester maternal serum levels of PAPPA, fhCG?, AFP, PlGF, and sTNFR1,
together with MC, are predictive of development of subsequent EOPE. These
markers, along with MC, form a suitable panel for predicting EOPE.
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