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10.1038/srep11196 http://scihub22266oqcxt.onion/10.1038/srep11196 C4468815!4468815!26080009     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26080009|t=2015. Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome |pdf=|usr=}}{{26080009}} gab.com Text Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26080009 #FOAvip Glutamic acid decarboxylase 65 (GAD65) and autoantibodies specific for GAD65 (GADA) are associated with autoimmune diseases including Stiff Person Syndrome (SPS) and Type 1 diabetes (T1D). GADA is recognized as a biomarker of value for clinical diagnosis and prognostication in these diseases. Nonetheless, it remains medically interesting to develop sensitive and specific assays to detect GAD65 preceding GADA emergence, and to monitor GADA-GAD65 immune complexes in blood samples. In the present study, we developed a highly sensitive proximity ligation assay to measure serum GAD65. This novel assay allowed detection of as little as 0.65?pg/ml GAD65. We were also able to detect immune complexes involving GAD65 and GADA. Both free GAD65 and GAD65-GADA levels were significantly higher in serum samples from SPS patients compared to healthy controls. The proximity ligation assays applied for detection of GAD65 and its immune complexes may thus enable improved diagnosis and better understanding of SPS. Twit Text FOAVip Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26080009 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26080009 #FOAvip English Wikipedia <ref>{{Cite pmid|26080009}}</ref> Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person Syndrome #MMPMID26080009 Gu Urban GJ; Friedman M; Ren P; Törn C; Fex M; Hampe CS; Lernmark Å; Landegren U; Kamali-Moghaddam M Sci Rep 2015[]; 5 (ä): ä PMID26080009show ga Glutamic acid decarboxylase 65 (GAD65) and autoantibodies specific for GAD65 (GADA) are associated with autoimmune diseases including Stiff Person Syndrome (SPS) and Type 1 diabetes (T1D). GADA is recognized as a biomarker of value for clinical diagnosis and prognostication in these diseases. Nonetheless, it remains medically interesting to develop sensitive and specific assays to detect GAD65 preceding GADA emergence, and to monitor GADA-GAD65 immune complexes in blood samples. In the present study, we developed a highly sensitive proximity ligation assay to measure serum GAD65. This novel assay allowed detection of as little as 0.65?pg/ml GAD65. We were also able to detect immune complexes involving GAD65 and GADA. Both free GAD65 and GAD65-GADA levels were significantly higher in serum samples from SPS patients compared to healthy controls. The proximity ligation assays applied for detection of GAD65 and its immune complexes may thus enable improved diagnosis and better understanding of SPS. äElevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person S(epmc).pdf DeepDyve Pubget Overpricing