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10.1007/s00418-015-1319-1 http://scihub22266oqcxt.onion/10.1007/s00418-015-1319-1 C4468792!4468792!25850409     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Histochem+Cell+Biol 2015 ; 144 (1): 1-11 Nephropedia Template TP {{tp|p=25850409|t=2015. Identification of receptor-type protein tyrosine phosphatase ? as a new marker for osteocytes |pdf=|usr=}}{{25850409}} gab.com Text Identification of receptor-type protein tyrosine phosphatase as a new marker for osteocytes JO: Histochem Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25850409 #FOAvip Osteocytes are the predominant cells in bone, where they form a cellular network and display important functions in bone homeostasis, phosphate metabolism and mechanical transduction. Several proteins strongly expressed by osteocytes are involved in these processes, e.g., sclerostin, DMP-1, PHEX, FGF23 and MEPE, while others are upregulated during differentiation of osteoblasts into osteocytes, e.g., osteocalcin and E11. The receptor-type protein tyrosine phosphatase µ (RPTP?) has been described to be expressed in cells which display a cellular network, e.g., endothelial and neuronal cells, and is implied in mechanotransduction. In a capillary outgrowth assay using metatarsals derived from RPTP?-knock-out/LacZ knock-in mice, we observed that the capillary structures grown out of the metatarsals were stained blue, as expected. Surprisingly, cells within the metatarsal bone tissue were positive for LacZ activity as well, indicating that RPTP? is also expressed by osteocytes. Subsequent histochemical analysis showed that within bone, RPTP? is expressed exclusively in early-stage osteocytes. Analysis of bone marrow cell cultures revealed that osteocytes are present in the nodules and an enzymatic assay enabled the quantification of the amount of osteocytes. No apparent bone phenotype was observed when tibiae of RPTP?-knock-out/LacZ knock-in mice were analyzed by ?CT at several time points during aging, although a significant reduction in cortical bone was observed in RPTP?-knock-out/LacZ knock-in mice at 20 weeks. Changes in trabecular bone were more subtle. Our data show that RPTP? is a new marker for osteocytes. Twit Text FOAVip Identification of receptor-type protein tyrosine phosphatase as a new marker for osteocytes ????Histochem Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25850409 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25850409 #FOAvip English Wikipedia <ref>{{Cite pmid|25850409}}</ref> Identification of receptor-type protein tyrosine phosphatase ? as a new marker for osteocytes #MMPMID25850409 de Rooij KE; van der Velde M; de Wilt E; Deckers MML; Bezemer M; Waarsing JH; Que I; Chan AB; Kaijzel EL; Löwik CWGM Histochem Cell Biol 2015[]; 144 (1): 1-11 PMID25850409show ga Osteocytes are the predominant cells in bone, where they form a cellular network and display important functions in bone homeostasis, phosphate metabolism and mechanical transduction. Several proteins strongly expressed by osteocytes are involved in these processes, e.g., sclerostin, DMP-1, PHEX, FGF23 and MEPE, while others are upregulated during differentiation of osteoblasts into osteocytes, e.g., osteocalcin and E11. The receptor-type protein tyrosine phosphatase µ (RPTP?) has been described to be expressed in cells which display a cellular network, e.g., endothelial and neuronal cells, and is implied in mechanotransduction. In a capillary outgrowth assay using metatarsals derived from RPTP?-knock-out/LacZ knock-in mice, we observed that the capillary structures grown out of the metatarsals were stained blue, as expected. Surprisingly, cells within the metatarsal bone tissue were positive for LacZ activity as well, indicating that RPTP? is also expressed by osteocytes. Subsequent histochemical analysis showed that within bone, RPTP? is expressed exclusively in early-stage osteocytes. Analysis of bone marrow cell cultures revealed that osteocytes are present in the nodules and an enzymatic assay enabled the quantification of the amount of osteocytes. No apparent bone phenotype was observed when tibiae of RPTP?-knock-out/LacZ knock-in mice were analyzed by ?CT at several time points during aging, although a significant reduction in cortical bone was observed in RPTP?-knock-out/LacZ knock-in mice at 20 weeks. Changes in trabecular bone were more subtle. Our data show that RPTP? is a new marker for osteocytes. äIdentification of receptor-type protein tyrosine phosphatase ? as a ne(epmc).pdf DeepDyve Pubget Overpricing