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10.1016/j.neo.2015.04.002 http://scihub22266oqcxt.onion/10.1016/j.neo.2015.04.002 C4468369!4468369!26025664     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26025664&cmd=llinks): Failed to open stream: HTTP request failed! 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Transmembrane-Bound IL-15?Promoted Epithelial-Mesenchymal Transition in Renal Cancer Cells Requires the Src-Dependent Akt/GSK-3?/?-Catenin Pathway12 |pdf=|usr=}}{{26025664}} gab.com Text Transmembrane-Bound IL-15 Promoted Epithelial-Mesenchymal Transition in Renal Cancer Cells Requires the Src-Dependent Akt/GSK-3 / -Catenin Pathway12 JO: Neoplasia http://www.kidney.de/pget.php?&tw=1&pmid=26025664 #FOAvip Intrarenal interleukin-15 (IL-15) plays a major role controlling epithelial survival and polarization both in physiological and pathologic conditions. Herein, we confirmed that human renal cell carcinomas (RCCs) express a membrane-bound IL-15 isoform displaying an unusual molecular weight of 27 kDa. Its stimulation with soluble IL-15 receptor ? chain (s-IL-15R?) triggers epithelial-mesenchymal transition (EMT) process as shown by the down-regulation of E-cadherin and zona occludens 1 and the up-regulation of vimentin and N-cadherin and promotes the migratory and invasive properties of RCC. S-IL-15R? treatment triggered the Src/PI3K/Akt/GSK-3? pathway and promoted ?-catenin nuclei translocation. Deactivation of this pathway by using Src-specific inhibitor PP2, PI3K inhibitor LY294002, and AKT inhibitor MK2206 hampered ?-catenin nuclei translocation and suppressed EMT, migration, and invasion of RCC. S-IL-15R? treatment also enhanced Src-dependent phosphorylation of focal adhesion kinase (FAK) and extracellular signal?regulated kinase (Erk1/2). FAK knockdown significantly decreased the migration and invasion of RCC, which suggest that Src-FAK signaling was involved in s-IL-15R??favored migration and invasion of RCC. At the same time, inhibitors of Erk1/2 also significantly decreased the migration and invasion of RCC but could not reverse s-IL-15R??induced EMT. Taken together, our results reveal that Src-dependent PI3K/Akt/GSK3b/?-catenin pathway is required for s-IL-15Ra?dependent induction of EMT in RCC, while Src-FAK and Src-Erk1/2 signaling were involved in s-IL-15R??promoted migration and invasion properties of RCC. Our study provides a better understanding of IL-15 signaling in RCC tumor progression, which may lead to novel targeted therapies and provide some suggestions when using IL-15 in clinic. Twit Text FOAVip Transmembrane-Bound IL-15 Promoted Epithelial-Mesenchymal Transition in Renal Cancer Cells Requires the Src-Dependent Akt/GSK-3 / -Catenin Pathway12 ????Neoplasia http://www.kidney.de/pget.php?&tw=1&pmid=26025664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26025664 #FOAvip English Wikipedia <ref>{{Cite pmid|26025664}}</ref> Transmembrane-Bound IL-15?Promoted Epithelial-Mesenchymal Transition in Renal Cancer Cells Requires the Src-Dependent Akt/GSK-3?/?-Catenin Pathway12 #MMPMID26025664 Yuan H; Meng X; Guo W; Cai P; Li W; Li Q; Wang W; Sun Y; Xu Q; Gu Y Neoplasia 2015[May]; 17 (5): 410-20 PMID26025664show ga Intrarenal interleukin-15 (IL-15) plays a major role controlling epithelial survival and polarization both in physiological and pathologic conditions. Herein, we confirmed that human renal cell carcinomas (RCCs) express a membrane-bound IL-15 isoform displaying an unusual molecular weight of 27 kDa. Its stimulation with soluble IL-15 receptor ? chain (s-IL-15R?) triggers epithelial-mesenchymal transition (EMT) process as shown by the down-regulation of E-cadherin and zona occludens 1 and the up-regulation of vimentin and N-cadherin and promotes the migratory and invasive properties of RCC. S-IL-15R? treatment triggered the Src/PI3K/Akt/GSK-3? pathway and promoted ?-catenin nuclei translocation. Deactivation of this pathway by using Src-specific inhibitor PP2, PI3K inhibitor LY294002, and AKT inhibitor MK2206 hampered ?-catenin nuclei translocation and suppressed EMT, migration, and invasion of RCC. S-IL-15R? treatment also enhanced Src-dependent phosphorylation of focal adhesion kinase (FAK) and extracellular signal?regulated kinase (Erk1/2). FAK knockdown significantly decreased the migration and invasion of RCC, which suggest that Src-FAK signaling was involved in s-IL-15R??favored migration and invasion of RCC. At the same time, inhibitors of Erk1/2 also significantly decreased the migration and invasion of RCC but could not reverse s-IL-15R??induced EMT. Taken together, our results reveal that Src-dependent PI3K/Akt/GSK3b/?-catenin pathway is required for s-IL-15Ra?dependent induction of EMT in RCC, while Src-FAK and Src-Erk1/2 signaling were involved in s-IL-15R??promoted migration and invasion properties of RCC. Our study provides a better understanding of IL-15 signaling in RCC tumor progression, which may lead to novel targeted therapies and provide some suggestions when using IL-15 in clinic. äTransmembrane-Bound IL-15?Promoted Epithelial-Mesenchymal Transition i(epmc).pdf DeepDyve Pubget Overpricing