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2015 ; 1
(1
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Persistent inflammatory, immunosuppressed, catabolic syndrome (PICS): A new
phenotype of multiple organ failure
#MMPMID26086042
Rosenthal MD
; Moore FA
J Adv Nutr Hum Metab
2015[Apr]; 1
(1
): ä PMID26086042
show ga
A new phenotype of multiple organ failure has appeared: Persistent Inflammatory,
Immunosuppressed, Catabolic Syndrome (PICS). Comorbidities and age >65 years have
been established as the leading risk factors for PICS. As the percentage of
elderly people continues to increase the prevalence of PICS in our ICUs will
surely grow. Malnutrition (despite appropriate supplementation), recurrent
nosocomial infections, frailty, ventilator dependence, and an indolent death
depicts the central theme that plagues PICS patients. Aligned with the recently
awarded P50 grant by NIGMS entitled, "PICS: A New Horizon for Surgical Critical
Care", and the University Of Florida's Sepsis and Critical Illness Research
Center will investigate the genetic make-up of PICS patients, better understand
frailty and the implication in trauma patients, and hopefully elucidate new
therapies. Currently, there are no therapies to combat PICS aside from
nutritional inference elaborated after reviewing the literature on Burns,
Cachexia, and Sarcopenia.