IDH1 and IDH2: Not Your Typical Oncogenes #MMPMID20227034
Reitman ZJ; Parsons DW; Yan H
Cancer Cell 2010[Mar]; 17 (3): 215-6 PMID20227034show ga
Oncogenes usually increase their normal function when activated. But seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.