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10.1016/j.ccr.2010.02.024

http://scihub22266oqcxt.onion/10.1016/j.ccr.2010.02.024
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C4467912!4467912!20227034
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suck abstract from ncbi

pmid20227034      Cancer+Cell 2010 ; 17 (3): 215-6
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  • IDH1 and IDH2: Not Your Typical Oncogenes #MMPMID20227034
  • Reitman ZJ; Parsons DW; Yan H
  • Cancer Cell 2010[Mar]; 17 (3): 215-6 PMID20227034show ga
  • Oncogenes usually increase their normal function when activated. But seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.
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