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10.1182/blood-2012-06-432443 http://scihub22266oqcxt.onion/10.1182/blood-2012-06-432443 C4467889!4467889 !23446736     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23446736 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood 2013 ; 121 (15 ): 3033-40 Nephropedia Template TP {{tp|p=23446736 |t=2013. A new approach for eradication of residual lymphoma cells by host nonreactive anti-third-party central memory CD8 T cells |pdf=|usr=}}{{23446736 }} gab.com Text A new approach for eradication of residual lymphoma cells by host nonreactive anti-third-party central memory CD8 T cells JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=23446736 #FOAvip Generation of T cells endowed with graft-versus-leukemia (GVL) and depleted of graft-versus-host (GVH) activity represents a highly desirable goal in bone marrow transplantation (BMT). Here, we demonstrate that donor anti-third-party CD8 T cells with central memory phenotype (Tcm) exhibit marked GVL reactivity through a unique T-cell receptor-independent mechanism. Thus, in a residual disease mouse model, Tcm therapy following autologous BMT led to significant survival prolongation, with 30% to 40% of the treated mice displaying long-term tumor-free survival. A more impressive finding was that infusion of donor Tcm in an allogeneic model rapidly eliminated residual lymphoma cells and led to long-term survival of 100% in the absence of GVH disease. Collectively, the strong GVL reactivity of anti-third-party Tcm, coupled with their demonstrated enhancement of bone marrow allografting, suggests that the use of Tcm therapy in conjunction with allogeneic T-cell-depleted BMT could be of particular benefit in patients with B-cell malignancies who cannot tolerate intensive myeloablative conditioning. Twit Text FOAVip A new approach for eradication of residual lymphoma cells by host nonreactive anti-third-party central memory CD8 T cells ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=23446736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23446736 #FOAvip English Wikipedia <ref>{{Cite pmid|23446736 }}</ref> A new approach for eradication of residual lymphoma cells by host nonreactive anti-third-party central memory CD8 T cells #MMPMID23446736 Lask A ; Ophir E ; Or-Geva N ; Cohen-Fredarow A ; Afik R ; Eidelstein Y ; Reich-Zeliger S ; Nathansohn B ; Edinger M ; Negrin RS ; Hagin D ; Reisner Y Blood 2013[Apr]; 121 (15 ): 3033-40 PMID23446736 show ga Generation of T cells endowed with graft-versus-leukemia (GVL) and depleted of graft-versus-host (GVH) activity represents a highly desirable goal in bone marrow transplantation (BMT). Here, we demonstrate that donor anti-third-party CD8 T cells with central memory phenotype (Tcm) exhibit marked GVL reactivity through a unique T-cell receptor-independent mechanism. Thus, in a residual disease mouse model, Tcm therapy following autologous BMT led to significant survival prolongation, with 30% to 40% of the treated mice displaying long-term tumor-free survival. A more impressive finding was that infusion of donor Tcm in an allogeneic model rapidly eliminated residual lymphoma cells and led to long-term survival of 100% in the absence of GVH disease. Collectively, the strong GVL reactivity of anti-third-party Tcm, coupled with their demonstrated enhancement of bone marrow allografting, suggests that the use of Tcm therapy in conjunction with allogeneic T-cell-depleted BMT could be of particular benefit in patients with B-cell malignancies who cannot tolerate intensive myeloablative conditioning. |Animals [MESH] |Apoptosis/immunology [MESH] |B-Lymphocytes/immunology/metabolism [MESH] |Bone Marrow Transplantation/methods [MESH] |CD8-Positive T-Lymphocytes/*immunology/metabolism [MESH] |Cell Line, Tumor [MESH] |Cytotoxicity, Immunologic/immunology [MESH] |Female [MESH] |Flow Cytometry [MESH] |Graft vs Host Disease/immunology [MESH] |Graft vs Leukemia Effect/immunology [MESH] |Immunologic Memory/*immunology [MESH] |Intercellular Adhesion Molecule-1/immunology/metabolism [MESH] |Lymphocyte Function-Associated Antigen-1/immunology/metabolism [MESH] |Lymphoma/*immunology/metabolism/pathology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mice, Nude [MESH] |Mice, Transgenic [MESH] |Neoplasm, Residual/*immunology [MESH] |Time Factors [MESH]A new approach for eradication of residual lymphoma cells by host nonr(epmc).pdf DeepDyve Pubget Overpricing