Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.15252/embr.201439505 http://scihub22266oqcxt.onion/10.15252/embr.201439505 C4467859!4467859 !25916856     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25916856 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25916856 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Rep 2015 ; 16 (6 ): 753-68 Nephropedia Template TP {{tp|p=25916856 |t=2015. LKB1 inhibition of NF-?B in B cells prevents T follicular helper cell differentiation and germinal center formation |pdf=|usr=}}{{25916856 }} gab.com Text LKB1 inhibition of NF- B in B cells prevents T follicular helper cell differentiation and germinal center formation JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25916856 #FOAvip T-cell-dependent antigenic stimulation drives the differentiation of B cells into antibody-secreting plasma cells and memory B cells, but how B cells regulate this process is unclear. We show that LKB1 expression in B cells maintains B-cell quiescence and prevents the premature formation of germinal centers (GCs). Lkb1-deficient B cells (BKO) undergo spontaneous B-cell activation and secretion of multiple inflammatory cytokines, which leads to splenomegaly caused by an unexpected expansion of T cells. Within this cytokine response, increased IL-6 production results from heightened activation of NF-?B, which is suppressed by active LKB1. Secreted IL-6 drives T-cell activation and IL-21 production, promoting T follicular helper (TFH ) cell differentiation and expansion to support a ~100-fold increase in steady-state GC B cells. Blockade of IL-6 secretion by BKO B cells inhibits IL-21 expression, a known inducer of TFH -cell differentiation and expansion. Together, these data reveal cell intrinsic and surprising cell extrinsic roles for LKB1 in B cells that control TFH -cell differentiation and GC formation, and place LKB1 as a central regulator of T-cell-dependent humoral immunity. Twit Text FOAVip LKB1 inhibition of NF- B in B cells prevents T follicular helper cell differentiation and germinal center formation ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25916856 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25916856 #FOAvip English Wikipedia <ref>{{Cite pmid|25916856 }}</ref> LKB1 inhibition of NF-?B in B cells prevents T follicular helper cell differentiation and germinal center formation #MMPMID25916856 Walsh NC ; Waters LR ; Fowler JA ; Lin M ; Cunningham CR ; Brooks DG ; Rehg JE ; Morse HC 3rd ; Teitell MA EMBO Rep 2015[Jun]; 16 (6 ): 753-68 PMID25916856 show ga T-cell-dependent antigenic stimulation drives the differentiation of B cells into antibody-secreting plasma cells and memory B cells, but how B cells regulate this process is unclear. We show that LKB1 expression in B cells maintains B-cell quiescence and prevents the premature formation of germinal centers (GCs). Lkb1-deficient B cells (BKO) undergo spontaneous B-cell activation and secretion of multiple inflammatory cytokines, which leads to splenomegaly caused by an unexpected expansion of T cells. Within this cytokine response, increased IL-6 production results from heightened activation of NF-?B, which is suppressed by active LKB1. Secreted IL-6 drives T-cell activation and IL-21 production, promoting T follicular helper (TFH ) cell differentiation and expansion to support a ~100-fold increase in steady-state GC B cells. Blockade of IL-6 secretion by BKO B cells inhibits IL-21 expression, a known inducer of TFH -cell differentiation and expansion. Together, these data reveal cell intrinsic and surprising cell extrinsic roles for LKB1 in B cells that control TFH -cell differentiation and GC formation, and place LKB1 as a central regulator of T-cell-dependent humoral immunity. |*Lymphocyte Activation [MESH] |AMP-Activated Protein Kinases [MESH] |Animals [MESH] |B-Lymphocytes/*immunology/*metabolism [MESH] |Cell Differentiation [MESH] |Germinal Center/*physiology [MESH] |Interleukin-21 [MESH] |Interleukin-6/immunology/metabolism [MESH] |Interleukins/immunology [MESH] |Mice [MESH] |NF-kappa B/genetics/*metabolism [MESH] |Protein Serine-Threonine Kinases/*genetics [MESH]LKB1 inhibition of NF-?B in B cells prevents T follicular helper cell (epmc).pdf DeepDyve Pubget Overpricing