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2015 ; 6
(5
): 1767-81
Nephropedia Template TP
gab.com Text
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English Wikipedia
Molecular imaging needles: dual-modality optical coherence tomography and
fluorescence imaging of labeled antibodies deep in tissue
#MMPMID26137379
Scolaro L
; Lorenser D
; Madore WJ
; Kirk RW
; Kramer AS
; Yeoh GC
; Godbout N
; Sampson DD
; Boudoux C
; McLaughlin RA
Biomed Opt Express
2015[May]; 6
(5
): 1767-81
PMID26137379
show ga
Molecular imaging using optical techniques provides insight into disease at the
cellular level. In this paper, we report on a novel dual-modality probe capable
of performing molecular imaging by combining simultaneous three-dimensional
optical coherence tomography (OCT) and two-dimensional fluorescence imaging in a
hypodermic needle. The probe, referred to as a molecular imaging (MI) needle, may
be inserted tens of millimeters into tissue. The MI needle utilizes double-clad
fiber to carry both imaging modalities, and is interfaced to a 1310-nm OCT system
and a fluorescence imaging subsystem using an asymmetrical double-clad fiber
coupler customized to achieve high fluorescence collection efficiency. We
present, to the best of our knowledge, the first dual-modality OCT and
fluorescence needle probe with sufficient sensitivity to image fluorescently
labeled antibodies. Such probes enable high-resolution molecular imaging deep
within tissue.