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2014 ; 24
(4
): 265-72
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New considerations in radiation treatment planning for brain tumors: neural
progenitor cell-containing niches
#MMPMID25219811
Kut C
; Janson Redmond K
Semin Radiat Oncol
2014[Oct]; 24
(4
): 265-72
PMID25219811
show ga
The purpose of this critical review is to explore the controversy regarding the
relationship between radiation dose to the neural progenitor cell (NPC) niches
and patient outcomes, in terms of both toxicity and tumor control. NPCs in the
subventricular zone (SVZ) and hippocampus are paradoxically associated with
long-term neurocognitive sequelae of brain irradiation, as well as resistance to
therapy and tumor recurrence. The reconciliation of these somewhat opposing
functions is challenging. Current literature suggests that radiation and other
treatments against the NPC in the hippocampus and the SVZ may influence patient
outcome. As a result, both the SVZ and the hippocampus could have important
implications on radiation treatment planning strategies, and future laboratory
and clinical evaluations will be critical in designing studies to optimize
treatment outcome, effectiveness, and safety.