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10.1186/s12967-015-0549-2

http://scihub22266oqcxt.onion/10.1186/s12967-015-0549-2
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suck abstract from ncbi


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pmid26048044      J+Transl+Med 2015 ; 13 (ä): ä
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  • Long-term kidney survival analyses in IgA nephropathy patients under steroids therapy: a case control study #MMPMID26048044
  • Yuan Y; Wang Q; Ni Z; Che X; Cao L; Shao X; Zhang M; Xie Y; Qi C; Zhou W; Tian L; Mou S
  • J Transl Med 2015[]; 13 (ä): ä PMID26048044show ga
  • Background: Corticosteroids are preferred to treat patients with active IgA nephropathy (IgAN), and beneficial effects from the short-term use of corticosteroids have been confirmed. However, a large number of patients will progress to end-stage renal disease after a long time follow-up. This study aimed to evaluate kidney disease progression and risk factors on kidney survival in IgAN patients receiving steroids treatment. Methods: Two hundred biopsy-proven IgAN patients who received corticosteroid therapy were enrolled and followed for a median period of 63.33 months. Risk factors on kidney survival were retrospectively investigated by the Cox proportional hazards model. Results: Of the two hundred patients, twenty patients showed progression of renal impairment at the end of follow-up. The median and interquartile range values for initial serum creatinine were 89.2 and 68.08?121.35 µmol/L, respectively. Multivariate Cox regression analyses revealed that relapse, non-remission, time-averaged eGFR (TA-eGFR), and time-averaged serum albumin (TA-ALB) were independently associated with the kidney progression. Those with TA-ALB levels <35 g/L and TA-eGFR levels <60 mL/min/1.73 m2 were less likely to recover from kidney progression. Patients were more likely to show kidney function deterioration, when they had non-remission or relapse after corticosteroids treatment. Conclusion: This study demonstrated that relapse, non-remission, TA-eGFR, and TA-ALB could serve as independent predictors of long term prognosis of IgAN patients receiving corticosteroid therapy.
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