Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s40484-013-0014-2 http://scihub22266oqcxt.onion/10.1007/s40484-013-0014-2 C4467561!4467561!26085954     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Quant+Biol 2013 ; 1 (3): 201-8 Nephropedia Template TP {{tp|p=26085954|t=2013. Population dynamics of cancer cells with cell state conversions |pdf=|usr=}}{{26085954}} gab.com Text Population dynamics of cancer cells with cell state conversions JO: Quant Biol http://www.kidney.de/pget.php?&tw=1&pmid=26085954 #FOAvip Cancer stem cell (CSC) theory suggests a cell-lineage structure in tumor cells in which CSCs are capable of giving rise to the other non-stem cancer cells (NSCCs) but not vice versa. However, an alternative scenario of bidirectional interconversions between CSCs and NSCCs was proposed very recently. Here we present a general population model of cancer cells by integrating conventional cell divisions with direct conversions between different cell states, namely, not only can CSCs differentiate into NSCCs by asymmetric cell division, NSCCs can also dedifferentiate into CSCs by cell state conversion. Our theoretical model is validated when applying the model to recent experimental data. It is also found that the transient increase in CSCs proportion initiated from the purified NSCCs subpopulation cannot be well predicted by the conventional CSC model where the conversion from NSCCs to CSCs is forbidden, implying that the cell state conversion is required especially for the transient dynamics. The theoretical analysis also gives the condition such that our general model can be equivalently reduced into a simple Markov chain with only cell state transitions keeping the same cell proportion dynamics. Twit Text FOAVip Population dynamics of cancer cells with cell state conversions ????Quant Biol http://www.kidney.de/pget.php?&tw=1&pmid=26085954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26085954 #FOAvip English Wikipedia <ref>{{Cite pmid|26085954}}</ref> Population dynamics of cancer cells with cell state conversions #MMPMID26085954 Zhou D; Wu D; Li Z; Qian M; Zhang MQ Quant Biol 2013[Sep]; 1 (3): 201-8 PMID26085954show ga Cancer stem cell (CSC) theory suggests a cell-lineage structure in tumor cells in which CSCs are capable of giving rise to the other non-stem cancer cells (NSCCs) but not vice versa. However, an alternative scenario of bidirectional interconversions between CSCs and NSCCs was proposed very recently. Here we present a general population model of cancer cells by integrating conventional cell divisions with direct conversions between different cell states, namely, not only can CSCs differentiate into NSCCs by asymmetric cell division, NSCCs can also dedifferentiate into CSCs by cell state conversion. Our theoretical model is validated when applying the model to recent experimental data. It is also found that the transient increase in CSCs proportion initiated from the purified NSCCs subpopulation cannot be well predicted by the conventional CSC model where the conversion from NSCCs to CSCs is forbidden, implying that the cell state conversion is required especially for the transient dynamics. The theoretical analysis also gives the condition such that our general model can be equivalently reduced into a simple Markov chain with only cell state transitions keeping the same cell proportion dynamics. äPopulation dynamics of cancer cells with cell state conversions (epmc).pdf DeepDyve Pubget Overpricing