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10.1097/WNR.0b013e32835542b0 http://scihub22266oqcxt.onion/10.1097/WNR.0b013e32835542b0 C4467540!4467540!22660168     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuroreport 2012 ; 23 (10): 621-6 Nephropedia Template TP {{tp|p=22660168|t=2012. Spreading of Alzheimer?s disease inflammatory signaling through soluble micro-RNA |pdf=|usr=}}{{22660168}} gab.com Text Spreading of Alzheimer s disease inflammatory signaling through soluble micro-RNA JO: Neuroreport http://www.kidney.de/pget.php?&tw=1&pmid=22660168 #FOAvip Alzheimer?s disease is a progressive, neurodegenerative disorder that develops within the limbic system, spreading radially into anatomically linked brain association areas as the disease progresses. Analysis of temporal-lobe association of neocortex-derived extracellular fluid and cerebrospinal fluid from Alzheimer?s disease patients shows an abundant presence of micro-RNA (miRNA), including the proinflammatory miRNA-146a and miRNA-155. Using a novel and highly sensitive LED-Northern dot-blot focusing technique, we detected the secretion of potentially pathogenic amounts of miRNA-146a and miRNA-155 from stressed human primary neural cells. A conditioned medium containing miRNA-146a and miRNA-155 was found to induce Alzheimer-type gene expression changes in control brain cells. These included downregulation in the expression of an important repressor of the innate immune response, complement factor H (CFH). These effects were neutralized using anti-miRNA strategies. Anti-miRNA-based therapeutics may provide a novel and efficacious treatment to stem the miRNA-mediated spreading of inflammatory signaling involved in Alzheimer?s disease. Twit Text FOAVip Spreading of Alzheimer s disease inflammatory signaling through soluble micro-RNA ????Neuroreport http://www.kidney.de/pget.php?&tw=1&pmid=22660168 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22660168 #FOAvip English Wikipedia <ref>{{Cite pmid|22660168}}</ref> Spreading of Alzheimer?s disease inflammatory signaling through soluble micro-RNA #MMPMID22660168 Lukiw WJ; Alexandrov PN; Zhao Y; Hill JM; Bhattacharjee S Neuroreport 2012[Jul]; 23 (10): 621-6 PMID22660168show ga Alzheimer?s disease is a progressive, neurodegenerative disorder that develops within the limbic system, spreading radially into anatomically linked brain association areas as the disease progresses. Analysis of temporal-lobe association of neocortex-derived extracellular fluid and cerebrospinal fluid from Alzheimer?s disease patients shows an abundant presence of micro-RNA (miRNA), including the proinflammatory miRNA-146a and miRNA-155. Using a novel and highly sensitive LED-Northern dot-blot focusing technique, we detected the secretion of potentially pathogenic amounts of miRNA-146a and miRNA-155 from stressed human primary neural cells. A conditioned medium containing miRNA-146a and miRNA-155 was found to induce Alzheimer-type gene expression changes in control brain cells. These included downregulation in the expression of an important repressor of the innate immune response, complement factor H (CFH). These effects were neutralized using anti-miRNA strategies. Anti-miRNA-based therapeutics may provide a novel and efficacious treatment to stem the miRNA-mediated spreading of inflammatory signaling involved in Alzheimer?s disease. äSpreading of Alzheimer?s disease inflammatory signaling through solubl(epmc).pdf DeepDyve Pubget Overpricing