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10.3892/ol.2015.3019 http://scihub22266oqcxt.onion/10.3892/ol.2015.3019 C4467318!4467318 !26137057     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26137057 &cmd=llinks): Failed to open stream: HTTP request failed! 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Anti-proliferative action of IL-6R-targeted antibody tocilizumab for non-small cell lung cancer cells |pdf=|usr=}}{{26137057 }} gab.com Text Anti-proliferative action of IL-6R-targeted antibody tocilizumab for non-small cell lung cancer cells JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26137057 #FOAvip In the present study we analyzed the anti-proliferative effect of tocilizumab, a humanized recombinant monoclonal interleukin 6 receptor (IL-6R) antibody, against non-small cell lung cancer (NSCLC) cells, including A549, H460, H358 and H1299 cells. The cell cycle distribution of NSCLCs was analyzed using fluorescence-activated cell sorting and gene expression using quantitative polymerase chain reaction. Cell lysates treated with tocilizumab were immunoblotted with antibodies against signal transducer and activator of transcription 3 (STAT3), phospho-STAT3, extracellular-signal-regulated kinases (ERK), phospho-ERK, nuclear factor ?B (NF?B) and phospho-NF?B. Significant growth inhibition of NSCLC cells was observed following treatment with tocilizumab. Proliferation was significantly decreased by approximately 10-40% in A549, H460, H1299 and H358 cells, with an inhibition rate that was comparable with that of the typical anticancer drugs methotrexate and 5-fluorouracil. NSCLC cell populations were accumulated in the sub-G1 phase by treatment with tocilizumab. Western blot analyses revealed a possible activation of the NF?B pathway by tocilizumab. Overall, these data indicate that tocilizumab has anticancer potency via apoptosis induction as an agonistic IL-6R regulator. Therefore, we suggest that this anti-IL-6R antibody may be utilized as a new targeting molecule for NSCLC therapies. Twit Text FOAVip Anti-proliferative action of IL-6R-targeted antibody tocilizumab for non-small cell lung cancer cells ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26137057 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26137057 #FOAvip English Wikipedia <ref>{{Cite pmid|26137057 }}</ref> Anti-proliferative action of IL-6R-targeted antibody tocilizumab for non-small cell lung cancer cells #MMPMID26137057 Kim NH ; Kim SK ; Kim DS ; Zhang D ; Park JA ; Yi H ; Kim JS ; Shin HC Oncol Lett 2015[May]; 9 (5 ): 2283-2288 PMID26137057 show ga In the present study we analyzed the anti-proliferative effect of tocilizumab, a humanized recombinant monoclonal interleukin 6 receptor (IL-6R) antibody, against non-small cell lung cancer (NSCLC) cells, including A549, H460, H358 and H1299 cells. The cell cycle distribution of NSCLCs was analyzed using fluorescence-activated cell sorting and gene expression using quantitative polymerase chain reaction. Cell lysates treated with tocilizumab were immunoblotted with antibodies against signal transducer and activator of transcription 3 (STAT3), phospho-STAT3, extracellular-signal-regulated kinases (ERK), phospho-ERK, nuclear factor ?B (NF?B) and phospho-NF?B. Significant growth inhibition of NSCLC cells was observed following treatment with tocilizumab. Proliferation was significantly decreased by approximately 10-40% in A549, H460, H1299 and H358 cells, with an inhibition rate that was comparable with that of the typical anticancer drugs methotrexate and 5-fluorouracil. NSCLC cell populations were accumulated in the sub-G1 phase by treatment with tocilizumab. Western blot analyses revealed a possible activation of the NF?B pathway by tocilizumab. Overall, these data indicate that tocilizumab has anticancer potency via apoptosis induction as an agonistic IL-6R regulator. Therefore, we suggest that this anti-IL-6R antibody may be utilized as a new targeting molecule for NSCLC therapies. äAnti-proliferative action of IL-6R-targeted antibody tocilizumab for n(epmc).pdf DeepDyve Pubget Overpricing