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10.1002/cpdd.92

http://scihub22266oqcxt.onion/10.1002/cpdd.92
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suck abstract from ncbi


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pmid26097789      Clin+Pharmacol+Drug+Dev 2014 ; 3 (3): 215-21
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  • Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Vilanterol, a Novel Inhaled Long-Acting ?-Agonist, in Children Aged 5?11 Years with Persistent Asthma: A Randomized Trial #MMPMID26097789
  • Oliver A; VanBuren S; Allen A; Hamilton M; Tombs L; Kempsford R; Qaqundah P
  • Clin Pharmacol Drug Dev 2014[May]; 3 (3): 215-21 PMID26097789show ga
  • This multi-center, randomized, double-blind, placebo-controlled, two-way crossover study was designed to characterize the safety, tolerability, pharmacokinetic, and pharmacodynamic profile of single and once-daily repeat doses of vilanterol 25?µg in children aged 5?11 years. Twenty-eight children with persistent asthma received a single inhaled dose of vilanterol 25?µg or placebo via the ELLIPTA? dry powder inhaler (DPI) on Day 1, followed 7 days later by once-daily treatment for 7 days. Nine (33%) subjects reported adverse events (AEs) with vilanterol 25?µg and 6 (23%) with placebo. No serious or drug-related AEs were reported; 3 subjects experienced upper respiratory tract infection (URTI) with vilanterol 25?µg versus none with placebo. Similar pharmacokinetic profiles of vilanterol 25?µg were observed irrespective of age or gender. No clinically relevant changes in heart rate, Fridericia's correction (QTcF), maximum glucose or minimum potassium parameters were observed during treatment with vilanterol 25?µg compared with placebo treatment. Vilanterol was well-tolerated and no long-acting ß2-agonist (LABA)-mediated AEs were observed. The pharmacokinetic profile of vilanterol 25?µg suggests exposure is similar regardless of age or gender in a pediatric population aged 5?11 years.
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