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10.1186/s13046-015-0180-3 http://scihub22266oqcxt.onion/10.1186/s13046-015-0180-3 C4467205!4467205!26071182     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Clin+Cancer+Res 2015 ; 34 (1): ä Nephropedia Template TP {{tp|p=26071182|t=2015. Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas |pdf=|usr=}}{{26071182}} gab.com Text Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas JO: J Exp Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26071182 #FOAvip Background: Piwi-interacting RNAs (piRNAs) are small RNAs of 27?30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest an important role in cancerogenesis. This study is the first one investigating their prognostic impact in clear cell renal cell cancer (ccRCC) patients. Methods: Three piRNAs (piR-30924, piR-57125, and piR-38756) selected on the basis of initial piRNA microarray analyses were determined using RT-qPCR in non-metastatic (n?=?76) and metastatic (n?=?30) ccRCC tissue at the time of nephrectomy in comparison to normal renal tissue (n?=?77) and tissue from distant ccRCC metastases (n?=?13). Primary clinical end points were recurrence-free and overall survival. Results: piR-57125 showed lower expression in metastatic than in non-metastatic tumors, whereas the expression of piR-30924 and piR-38756 increased in metastatic tumors. The higher expression of piR-30924 and piR-38756 as well as the lower expression of piR-57125 in metastatic primary tumors were significantly associated with tumor recurrence and overall survival. Multivariate Cox regression analyses revealed both piR-30924 and piR-57125 as independent prognostic predictors. This impact was even more pronounced in non-metastatic patients. Conclusions: This study demonstrates that the expression levels of these piRNAs in primary non-metastatic and metastatic ccRCC tissue can serve as potential prognostic biomarkers in combination with clinicopathological factors. Electronic supplementary material: The online version of this article (doi:10.1186/s13046-015-0180-3) contains supplementary material, which is available to authorized users. Twit Text FOAVip Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas ????J Exp Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=26071182 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26071182 #FOAvip English Wikipedia <ref>{{Cite pmid|26071182}}</ref> Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas #MMPMID26071182 Busch J; Ralla B; Jung M; Wotschofsky Z; Trujillo-Arribas E; Schwabe P; Kilic E; Fendler A; Jung K J Exp Clin Cancer Res 2015[]; 34 (1): ä PMID26071182show ga Background: Piwi-interacting RNAs (piRNAs) are small RNAs of 27?30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest an important role in cancerogenesis. This study is the first one investigating their prognostic impact in clear cell renal cell cancer (ccRCC) patients. Methods: Three piRNAs (piR-30924, piR-57125, and piR-38756) selected on the basis of initial piRNA microarray analyses were determined using RT-qPCR in non-metastatic (n?=?76) and metastatic (n?=?30) ccRCC tissue at the time of nephrectomy in comparison to normal renal tissue (n?=?77) and tissue from distant ccRCC metastases (n?=?13). Primary clinical end points were recurrence-free and overall survival. Results: piR-57125 showed lower expression in metastatic than in non-metastatic tumors, whereas the expression of piR-30924 and piR-38756 increased in metastatic tumors. The higher expression of piR-30924 and piR-38756 as well as the lower expression of piR-57125 in metastatic primary tumors were significantly associated with tumor recurrence and overall survival. Multivariate Cox regression analyses revealed both piR-30924 and piR-57125 as independent prognostic predictors. This impact was even more pronounced in non-metastatic patients. Conclusions: This study demonstrates that the expression levels of these piRNAs in primary non-metastatic and metastatic ccRCC tissue can serve as potential prognostic biomarkers in combination with clinicopathological factors. Electronic supplementary material: The online version of this article (doi:10.1186/s13046-015-0180-3) contains supplementary material, which is available to authorized users. äPiwi-interacting RNAs as novel prognostic markers in clear cell renal (epmc).pdf DeepDyve Pubget Overpricing