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10.18632/oncotarget.3214 http://scihub22266oqcxt.onion/10.18632/oncotarget.3214 C4467129!4467129 !25669977     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25669977 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (7 ): 4992-5004 Nephropedia Template TP {{tp|p=25669977 |t=2015. The heparan sulfate mimetic PG545 interferes with Wnt/?-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine |pdf=|usr=}}{{25669977 }} gab.com Text The heparan sulfate mimetic PG545 interferes with Wnt/ -catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25669977 #FOAvip The heparan sulfate mimetic PG545 has been shown to exert anti-angiogenic and anti-metastatic activity in vitro and in vivo cancer models. Although much of this activity has been attributed to inhibition of heparanase and heparan sulfate-binding growth factors, it was hypothesized that PG545 may additionally disrupt Wnt signaling, an important pathway underlying the malignancy of pancreatic cancer. We show that PG545, by directly interacting with Wnt3a and Wnt7a, inhibits Wnt/?-catenin signaling leading to inhibition of proliferation in pancreatic tumor cell lines. Additionally, we demonstrate for the first time that the combination of PG545 with gemcitabine has strong synergistic effects on viability, motility and apoptosis induction in several pancreatic cell lines. In an orthotopic xenograft mouse model, combination of PG545 with gemcitabine efficiently inhibited tumor growth and metastasis compared to single treatment alone. Also, PG545 treatment alone decreased the levels of ?-catenin and its downstream targets, cyclin D1, MMP-7 and VEGF which is consistent with our in vitro data. Collectively, our findings suggest that PG545 exerts anti-tumor activity by disrupting Wnt/?-catenin signaling and combination with gemcitabine should be considered as a novel therapeutic strategy for pancreatic cancer treatment. Twit Text FOAVip The heparan sulfate mimetic PG545 interferes with Wnt/ -catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25669977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25669977 #FOAvip English Wikipedia <ref>{{Cite pmid|25669977 }}</ref> The heparan sulfate mimetic PG545 interferes with Wnt/?-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine #MMPMID25669977 Jung DB ; Yun M ; Kim EO ; Kim J ; Kim B ; Jung JH ; Wang E ; Mukhopadhyay D ; Hammond E ; Dredge K ; Shridhar V ; Kim SH Oncotarget 2015[Mar]; 6 (7 ): 4992-5004 PMID25669977 show ga The heparan sulfate mimetic PG545 has been shown to exert anti-angiogenic and anti-metastatic activity in vitro and in vivo cancer models. Although much of this activity has been attributed to inhibition of heparanase and heparan sulfate-binding growth factors, it was hypothesized that PG545 may additionally disrupt Wnt signaling, an important pathway underlying the malignancy of pancreatic cancer. We show that PG545, by directly interacting with Wnt3a and Wnt7a, inhibits Wnt/?-catenin signaling leading to inhibition of proliferation in pancreatic tumor cell lines. Additionally, we demonstrate for the first time that the combination of PG545 with gemcitabine has strong synergistic effects on viability, motility and apoptosis induction in several pancreatic cell lines. In an orthotopic xenograft mouse model, combination of PG545 with gemcitabine efficiently inhibited tumor growth and metastasis compared to single treatment alone. Also, PG545 treatment alone decreased the levels of ?-catenin and its downstream targets, cyclin D1, MMP-7 and VEGF which is consistent with our in vitro data. Collectively, our findings suggest that PG545 exerts anti-tumor activity by disrupting Wnt/?-catenin signaling and combination with gemcitabine should be considered as a novel therapeutic strategy for pancreatic cancer treatment. |Angiogenesis Inhibitors/administration & dosage/pharmacology [MESH] |Animals [MESH] |Antineoplastic Combined Chemotherapy Protocols/*pharmacology [MESH] |Biomimetic Materials/administration & dosage/pharmacology [MESH] |Carcinogenesis/drug effects [MESH] |Carcinoma, Pancreatic Ductal/drug therapy/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Deoxycytidine/administration & dosage/*analogs & derivatives/pharmacology [MESH] |Drug Synergism [MESH] |Female [MESH] |Gemcitabine [MESH] |Humans [MESH] |Mice [MESH] |Mice, Nude [MESH] |Pancreatic Neoplasms/*drug therapy/metabolism/pathology [MESH] |Random Allocation [MESH] |Saponins/administration & dosage/*pharmacology [MESH] |Wnt Signaling Pathway/*drug effects [MESH] |Xenograft Model Antitumor Assays [MESH]The heparan sulfate mimetic PG545 interferes with Wnt/?-catenin signal(epmc).pdf DeepDyve Pubget Overpricing