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10.18632/oncotarget.3210

http://scihub22266oqcxt.onion/10.18632/oncotarget.3210
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C4467125!4467125 !25669973
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suck abstract from ncbi


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pmid25669973
      Oncotarget 2015 ; 6 (7 ): 4936-52
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  • Galectin-3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with ?-catenin #MMPMID25669973
  • Chung LY ; Tang SJ ; Wu YC ; Sun GH ; Liu HY ; Sun KH
  • Oncotarget 2015[Mar]; 6 (7 ): 4936-52 PMID25669973 show ga
  • Cancer stem cells (CSCs) are comprised of a rare sub-population of cells in tumors that have been proposed to be responsible for high recurrence rates and resistance to chemotherapy. Galectins are highly expressed in cancers that correlate with the aggressiveness of tumors. Galectins may also promote the resistance of cancer cells to chemotherapy. However, the role of galectins in CSCs remains unknown. In this study, sphere formation was used to enrich H1299 human lung CSCs that had self-renewal ability, advanced tumorigenic potential, and that highly expressed stem/progenitor cell markers such as Oct4, Sox2, Nanog, and CD133. A novel candidate molecule, galectin-3, for stemness was found in lung CSCs. The expression of galectin-3 robustly increased in lung cancer spheres over serial passages, but its suppression in the H1299 monolayer or spheres resulted in reduced expression of stemness-related genes, sphere-forming ability, tumorigenicity, chemoresistance, and tumor initiation in mice. Notably, the overexpression of galectin-3 in A549 lung cancer cells, which have low capability to grow as tumor spheres, promoted CSC formation. ?-catenin activity was increased in H1299 spheres and counteracted by galectin-3 suppression. Thus, galectin-3 may act as a cofactor by interacting with ?-catenin to augment the transcriptional activities of stemness-related genes. Furthermore, galectin-3 expression correlated with tumor progression and expressions of ?-catenin and CSC marker CD133 in lung cancer tissues. Targeting galectin-3 signaling may provide a new strategy for lung cancer treatment by inhibiting stem-like properties.
  • |Animals [MESH]
  • |Carcinogenesis/metabolism/pathology [MESH]
  • |Carcinogens/analysis/metabolism [MESH]
  • |Cell Line, Tumor [MESH]
  • |Cell Proliferation/physiology [MESH]
  • |Galectin 3/analysis/*metabolism [MESH]
  • |HEK293 Cells [MESH]
  • |Heterografts [MESH]
  • |Humans [MESH]
  • |Immunohistochemistry [MESH]
  • |Lung Neoplasms/chemistry/*metabolism/pathology [MESH]
  • |Mice, Inbred NOD [MESH]
  • |Mice, SCID [MESH]
  • |Tissue Array Analysis [MESH]


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