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10.1161/ATVBAHA.112.254219 http://scihub22266oqcxt.onion/10.1161/ATVBAHA.112.254219 C4467024!4467024!23087364     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arterioscler+Thromb+Vasc+Biol 2012 ; 32 (12): 3012-23 Nephropedia Template TP {{tp|p=23087364|t=2012. Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation |pdf=|usr=}}{{23087364}} gab.com Text Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation JO: Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=23087364 #FOAvip Objective: Activation of inflammatory pathways plays a critical role in the development of abdominal aortic aneurysms (AAA). Notch1 signaling is a significant regulator of the inflammatory response; however, its role in AAA is unknown. Methods and Results: In an angiotensin II (AngII)-induced mouse model of AAA, activation of Notch1 signaling was observed in the aortic aneurysmal tissue of Apoe?/? mice and a similar activation of Notch1 was observed in aneurysms of humans undergoing AAA repair. Notch1 haploinsufficiency significantly reduced the incidence of AAA in Apoe?/? mice in response to AngII. Reconstitution of bone marrow-derived cells from Notch1+/?; Apoe?/? mice (donor) in lethally irradiated Apoe?/? mice (recipient) decreased occurrence of aneurysm. Flow cytometry and immunohistochemistry demonstrated that Notch1 haploinsufficiency prevented the influx of inflammatory macrophages at the aneurysmal site by causing defects in macrophage migration and proliferation. Additionally, there was an overall reduction in the inflammatory burden in the aorta of the Notch1+/?;Apoe?/? mice as compared to the Apoe?/? mice. Lastly, pharmacologic inhibition of Notch1 signaling also prevented AAA formation and progression in Apoe?/? mice. Conclusion: Our data suggest that decreased levels of Notch1 protect against the formation of AAA by preventing macrophage recruitment and attenuating the inflammatory response in the aorta. Twit Text FOAVip Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation ????Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=23087364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23087364 #FOAvip English Wikipedia <ref>{{Cite pmid|23087364}}</ref> Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation #MMPMID23087364 Hans CP; Koenig SN; Huang N; Cheng J; Beceiro S; Guggilam A; Kuivaniemi H; Partida-Sánchez S; Garg V Arterioscler Thromb Vasc Biol 2012[Dec]; 32 (12): 3012-23 PMID23087364show ga Objective: Activation of inflammatory pathways plays a critical role in the development of abdominal aortic aneurysms (AAA). Notch1 signaling is a significant regulator of the inflammatory response; however, its role in AAA is unknown. Methods and Results: In an angiotensin II (AngII)-induced mouse model of AAA, activation of Notch1 signaling was observed in the aortic aneurysmal tissue of Apoe?/? mice and a similar activation of Notch1 was observed in aneurysms of humans undergoing AAA repair. Notch1 haploinsufficiency significantly reduced the incidence of AAA in Apoe?/? mice in response to AngII. Reconstitution of bone marrow-derived cells from Notch1+/?; Apoe?/? mice (donor) in lethally irradiated Apoe?/? mice (recipient) decreased occurrence of aneurysm. Flow cytometry and immunohistochemistry demonstrated that Notch1 haploinsufficiency prevented the influx of inflammatory macrophages at the aneurysmal site by causing defects in macrophage migration and proliferation. Additionally, there was an overall reduction in the inflammatory burden in the aorta of the Notch1+/?;Apoe?/? mice as compared to the Apoe?/? mice. Lastly, pharmacologic inhibition of Notch1 signaling also prevented AAA formation and progression in Apoe?/? mice. Conclusion: Our data suggest that decreased levels of Notch1 protect against the formation of AAA by preventing macrophage recruitment and attenuating the inflammatory response in the aorta. äInhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mi(epmc).pdf DeepDyve Pubget Overpricing