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2015 ; 8
(4
): 4033-43
Nephropedia Template TP
gab.com Text
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English Wikipedia
Erythropoietin and erythropoietin receptor in hepatocellular carcinoma:
correlation with vasculogenic mimicry and poor prognosis
#MMPMID26097591
Yang Z
; Sun B
; Zhao X
; Shao B
; An J
; Gu Q
; Wang Y
; Dong X
; Zhang Y
; Qiu Z
Int J Clin Exp Pathol
2015[]; 8
(4
): 4033-43
PMID26097591
show ga
To evaluate erythropoietin (Epo) and erythropoietin receptor (EpoR) expression,
its relationship with vasculogenic mimicry (VM) and its prognostic value in human
hepatocellular carcinoma (HCC), we examined Epo/EpoR expression and VM formation
using immunohistochemistry and CD31/PAS (periodic acid-Schiff) double staining on
92 HCC specimens. The correlation between Epo/EpoR expression and VM formation
was analyzed using two-tailed Chi-square test and Spearman correlation analysis.
Survival curves were generated using Kaplan-Meier method. Multivariate analysis
was performed using Cox regression model to assess the prognostic values. Results
showed positive correlation between Epo/EpoR expression and VM formation (P <
0.05). Patients with Epo or EpoR expression exhibited poorer overall survival
(OS) than Epo-negative or EpoR-negative patients (P < 0.05).
Epo-positive/VM-positive and EpoR-positive/VM-positive patients had the worst OS
(P < 0.05). In multivariate survival analysis, age, Epo and EpoR were independent
prognostic factors related to OS. These results will provide evidence for further
research on HCC microcirculation patterns and also will provide new possible
targets for HCC diagnosis and treatment.