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2015 ; 8
(4
): 3857-63
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Increased expression of metastasis-associated in colon cancer-1 in renal cell
carcinoma is associated with poor prognosis
#MMPMID26097569
Jin Z
; Xu N
; Guo K
; Xu P
; Li P
; Zhang Y
; Li X
; Zheng S
; Liu C
; Xu A
; Huang P
Int J Clin Exp Pathol
2015[]; 8
(4
): 3857-63
PMID26097569
show ga
Metastasis-associated in colon cancer-1 (MACC1) expression in tumor specimens is
an independent prognostic indicator of metastasis, which has recently gained
considerable attention in cancer research, due to its overexpression in several
types of carcinoma. However, MACC1 expression patterns and its possible role in
renal cell carcinoma remain unknown. This study aimed to investigate MACC1
expression in renal cell carcinoma via immunohistochemical analysis and determine
the relationship between MACC1 expression and cancer prognosis. Positive MACC1
expression was found to significantly correlate with distant metastasis and TNM
stage (P < 0.05). A Kaplan-Meier survival analysis revealed that patients with
higher MACC1 expression had a significantly lower disease-free rate (P < 0.05).
These results indicate that MACC1 expression is significantly associated with
prognosis in patients with renal cell carcinoma. To the best of our knowledge,
this is the first study on the significance of MACC1 as a prognostic marker in
renal cell carcinoma. MACC1 expression may be a useful target for the development
of new therapeutic approaches, including molecular targeted therapeutic agents,
for renal cell carcinoma.