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2015 ; 8
(4
): 3710-8
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Decreased SATB2 expression is associated with metastasis and poor prognosis in
human clear cell renal cell carcinoma
#MMPMID26097552
Guo C
; Xiong D
; Yao X
; Gu W
; Zhang H
; Yang B
; Peng B
; Liu M
; Zheng J
Int J Clin Exp Pathol
2015[]; 8
(4
): 3710-8
PMID26097552
show ga
In this study, we investigate the expression and role of special AT-rich
sequence-binding protein-2 (SATB2) in clear cell renal cell carcinoma (ccRCC)
tissue, and to evaluate the clinical and prognostic significance of SATB2 protein
in patients with ccRCC. The expression of SATB2 and SATB1 was examined in ccRCC
tissue by Western blotting, real-time PCR and immunohistochemical staining. The
association between clinicopathological features and SATB2 level was
investigated. The correlation of SATB2 expression with overall survival was also
analyzed. The expression of SATB2 protein in tumor tissues was much lower than
that in paired normal tissues. The overall survival of the patients with high
SATB2 expression was significantly higher than that of the low SATB2 expression
group. Low or negative SATB2 expression was significantly correlated with AJCC
staging and Furman grade in ccRCC. In contrast, the expression of SATB1 was
significantly higher in adjacent tumor tissue than that in normal and tumor
tissues. This study provides the first evidence of the expression and clinical
significance of SATB2 in ccRCC. Our data suggest that SATB2 functions as a tumor
suppressor in the development and progression of ccRCC, and is thereby implicated
as a valuable prognostic marker for ccRCC patients.