Krüppel-like factors 4 and 5 expression and their involvement in differentiation
of oral carcinomas
#MMPMID26097551
Shibata M
; Chiba T
; Matsuoka T
; Mihara N
; Kawashiri S
; Imai K
Int J Clin Exp Pathol
2015[]; 8
(4
): 3701-9
PMID26097551
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Proliferation-differentiation balance of epithelial cells is regulated by
Krüppel-like factors (KLF) 4 and 5, and the unbalanced expression relates to
carcinoma progression. However, little is known about the expression and role in
oral carcinomas. This study examined expression of KLF4 and KLF 5 in the
carcinomas by immunohistochemistry (n = 67) and the involvement in proliferation
and differentiation of carcinoma cells. KLF4 was detected in keratinizing
carcinoma cells and KLF5 in non-keratinizing cells. KLF4 staining declined in the
patient with lymph node metastasis (P < 0.05) and in parallel with the
histological dedifferentiation (P = 0.09). Exogenous overexpression of KLF4
arranged cells in a cobble-like structure with desmosomes and KLF5 elongated
cells like fibroblasts without desmosomes. KLF4 suppressed fibronectin
expression, and KLF5 down-regulated and degraded E-cadherin. The proliferation
was not affected by KLFs. Thus, down-regulation of KLF4 and up-regulation of KLF5
may stimulate oral carcinoma progression through the dedifferentiation of
carcinoma cells.
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