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Protective effects of calcitriol on diabetic nephropathy are mediated by down
regulation of TGF-?1 and CIP4 in diabetic nephropathy rat
#MMPMID26097534
Yu R
; Mao J
; Yang Y
; Zhang Y
; Tian Y
; Zhu J
Int J Clin Exp Pathol
2015[]; 8
(4
): 3503-12
PMID26097534
show ga
OBJECTIVE: To explore the protective effects of calcitriol on diabetic
nephropathy by modulating the expressions of transforming growth factor-beta 1
(TGF-?1) and Cdc42 interacting protein-4 (CIP4). METHODS: Streptozotocin-induced
diabetic nephropathy rats (n=36) were randomly divided into control group
(control-H, control-M, control-L) and calcitriol group (calcitriol-H,
calcitriol-M, calcitriol-L). The expression of TGF-?1 gradually decreased in
control-H, control-M and control-L subgroups by injection of different virus
vectors. Peanut oil and calcitriol were given to control and calcitriol group,
respectively. The expressions of TGF-?1 and CIP4 in kidney, the pathology, and
the renal function and lipid profiles were compared between control and
calcitriol treatment groups. RESULTS: In the control group, the higher level of
TGF-?1 was associated with more severe glomerular pathology (P<0.05). There is a
positive correlation between the expression of CIP4 and TGF-?1. Control-H
subgroup had significant more severe kidney disease, higher levels of
cholesterol, triglyceride, blood glucose, blood urea nitrogen (BUN) and
creatinine (Cr) than control-M and control-L subgroups. After calcitriol
treatment, the expression of TGF-?1 and CIP4 were significantly decreased
compared to the corresponding control subgroups (all P<0.05). Renal fibrosis and
pathological changes were markedly improved. The levels of cholesterol,
triglyceride, blood glucose, BUN and Cr were significantly reduced (P<0.05).
CONCLUSION: Calcitriol may protect diabetic nephropathy from fibrosis via
inhibition of TGF-?1 and CIP4.
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