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10.1073/pnas.1508815112 http://scihub22266oqcxt.onion/10.1073/pnas.1508815112 C4466728!4466728!26040000     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (23): 7165-70 Nephropedia Template TP {{tp|p=26040000|t=2015. Metformin increases degradation of phospholamban via autophagy in cardiomyocytes |pdf=|usr=}}{{26040000}} gab.com Text Metformin increases degradation of phospholamban via autophagy in cardiomyocytes JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26040000 #FOAvip Phospholamban (PLN) can regulate Ca2+ uptake rates in the sarcoplasmic reticulum in cardiomyocytes. However, the mechanisms that control PLN levels are not fully understood. This study shows that PLN degradation depends on ubiquitinylation of its lysine 3 residue and p62-mediated selective autophagy. Metformin was shown to accelerate autophagy and to induce PLN degradation, resulting in increased Ca2+ uptake. These results suggest that changes in PLN degradation could account for the cardiac inotropic effects of metformin. Twit Text FOAVip Metformin increases degradation of phospholamban via autophagy in cardiomyocytes ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26040000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26040000 #FOAvip English Wikipedia <ref>{{Cite pmid|26040000}}</ref> Metformin increases degradation of phospholamban via autophagy in cardiomyocytes #MMPMID26040000 Teng ACT; Miyake T; Yokoe S; Zhang L; Rezende LM; Sharma P; MacLennan DH; Liu PP; Gramolini AO Proc Natl Acad Sci U S A 2015[Jun]; 112 (23): 7165-70 PMID26040000show ga Phospholamban (PLN) can regulate Ca2+ uptake rates in the sarcoplasmic reticulum in cardiomyocytes. However, the mechanisms that control PLN levels are not fully understood. This study shows that PLN degradation depends on ubiquitinylation of its lysine 3 residue and p62-mediated selective autophagy. Metformin was shown to accelerate autophagy and to induce PLN degradation, resulting in increased Ca2+ uptake. These results suggest that changes in PLN degradation could account for the cardiac inotropic effects of metformin. äMetformin increases degradation of phospholamban via autophagy in card(epmc).pdf DeepDyve Pubget Overpricing