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10.1073/pnas.1507499112 http://scihub22266oqcxt.onion/10.1073/pnas.1507499112 C4466718!4466718!26039995     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (23): 7243-8 Nephropedia Template TP {{tp|p=26039995|t=2015. Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition |pdf=|usr=}}{{26039995}} gab.com Text Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26039995 #FOAvip The role of signal transducer and activator of transcription 3 (STAT3) pathway in hepatic stellate cells (HSCs) remains unclear. Using sorafenib and its derivative SC-1, we demonstrated the significant role of STAT3 pathway in liver fibrogenesis. We further found that STAT3 pathway of HSCs overexpressed in chronic hepatitis B patients with advanced fibrosis, therefore STAT3 may serve as a promising fibrotic biomarker and target. Furthermore, SHP-1 phosphatase-direct STAT3 inhibition may represent a previously unidentified strategy for antifibrotic drug discovery. Twit Text FOAVip Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26039995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26039995 #FOAvip English Wikipedia <ref>{{Cite pmid|26039995}}</ref> Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition #MMPMID26039995 Su TH; Shiau CW; Jao P; Liu CH; Liu CJ; Tai WT; Jeng YM; Yang HC; Tseng TC; Huang HP; Cheng HR; Chen PJ; Chen KF; Kao JH; Chen DS Proc Natl Acad Sci U S A 2015[Jun]; 112 (23): 7243-8 PMID26039995show ga The role of signal transducer and activator of transcription 3 (STAT3) pathway in hepatic stellate cells (HSCs) remains unclear. Using sorafenib and its derivative SC-1, we demonstrated the significant role of STAT3 pathway in liver fibrogenesis. We further found that STAT3 pathway of HSCs overexpressed in chronic hepatitis B patients with advanced fibrosis, therefore STAT3 may serve as a promising fibrotic biomarker and target. Furthermore, SHP-1 phosphatase-direct STAT3 inhibition may represent a previously unidentified strategy for antifibrotic drug discovery. äSorafenib and its derivative SC-1 exhibit antifibrotic effects through(epmc).pdf DeepDyve Pubget Overpricing