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10.1073/pnas.1504671112 http://scihub22266oqcxt.onion/10.1073/pnas.1504671112 C4466715!4466715!26039994     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26039994.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (23): E3000-9 Nephropedia Template TP {{tp|p=26039994|t=2015. Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-? receptor I to inhibit TGF-? signaling |pdf=|usr=}}{{26039994}} gab.com Text Human ortholog of Drosophila Melted impedes SMAD2 release from TGF- receptor I to inhibit TGF- signaling JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26039994 #FOAvip Ventricular zone expressed pleckstrin homology domain-containing 1 (VEPH1) is among genes on chromosome 3q24-26, a region amplified in several cancers. Although little is known of mammalian VEPH1, its Drosophila ortholog, Melted, is involved in neural and eye development, metabolism, and size determination through effects on Forkhead box O, target of rapamycin, and Hippo signaling. We show that VEPH1 expression affects similar gene categories as Melted and potently inhibits transforming growth factor-? (TGF-?) signaling. VEPH1 interacts with TGF-? type I receptor (T?RI) and inhibits dissociation of activated Sma- and Mad-related protein 2 from T?RI, resulting in impaired TGF-? signaling. TGF-? acts initially as a tumor suppressor through its cytostatic activity, but subsequently promotes tumor progression. These findings suggest that VEPH1 could affect TGF-? activity during cancer development/progression. Twit Text FOAVip Human ortholog of Drosophila Melted impedes SMAD2 release from TGF- receptor I to inhibit TGF- signaling ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26039994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26039994 #FOAvip English Wikipedia <ref>{{Cite pmid|26039994}}</ref> Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-? receptor I to inhibit TGF-? signaling #MMPMID26039994 Shathasivam P; Kollara A; Ringuette MJ; Virtanen C; Wrana JL; Brown TJ Proc Natl Acad Sci U S A 2015[Jun]; 112 (23): E3000-9 PMID26039994show ga Ventricular zone expressed pleckstrin homology domain-containing 1 (VEPH1) is among genes on chromosome 3q24-26, a region amplified in several cancers. Although little is known of mammalian VEPH1, its Drosophila ortholog, Melted, is involved in neural and eye development, metabolism, and size determination through effects on Forkhead box O, target of rapamycin, and Hippo signaling. We show that VEPH1 expression affects similar gene categories as Melted and potently inhibits transforming growth factor-? (TGF-?) signaling. VEPH1 interacts with TGF-? type I receptor (T?RI) and inhibits dissociation of activated Sma- and Mad-related protein 2 from T?RI, resulting in impaired TGF-? signaling. TGF-? acts initially as a tumor suppressor through its cytostatic activity, but subsequently promotes tumor progression. These findings suggest that VEPH1 could affect TGF-? activity during cancer development/progression. äHuman ortholog of Drosophila Melted impedes SMAD2 release from TGF-? r(epmc).pdf DeepDyve Pubget Overpricing