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10.1073/pnas.1504671112 http://scihub22266oqcxt.onion/10.1073/pnas.1504671112 C4466715!4466715 !26039994     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26039994 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (23 ): E3000-9 Nephropedia Template TP {{tp|p=26039994 |t=2015. Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-? receptor I to inhibit TGF-? signaling |pdf=|usr=}}{{26039994 }} gab.com Text Human ortholog of Drosophila Melted impedes SMAD2 release from TGF- receptor I to inhibit TGF- signaling JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26039994 #FOAvip Drosophila melted encodes a pleckstrin homology (PH) domain-containing protein that enables normal tissue growth, metabolism, and photoreceptor differentiation by modulating Forkhead box O (FOXO), target of rapamycin, and Hippo signaling pathways. Ventricular zone expressed PH domain-containing 1 (VEPH1) is the mammalian ortholog of melted, and although it exhibits tissue-restricted expression during mouse development and is potentially amplified in several human cancers, little is known of its function. Here we explore the impact of VEPH1 expression in ovarian cancer cells by gene-expression profiling. In cells with elevated VEPH1 expression, transcriptional programs associated with metabolism and FOXO and Hippo signaling were affected, analogous to what has been reported for Melted. We also observed altered regulation of multiple transforming growth factor-? (TGF-?) target genes. Global profiling revealed that elevated VEPH1 expression suppressed TGF-?-induced transcriptional responses. This inhibitory effect was verified on selected TGF-? target genes and by reporter gene assays in multiple cell lines. We further demonstrated that VEPH1 interacts with TGF-? receptor I (T?RI) and inhibits nuclear accumulation of activated Sma- and Mad-related protein 2 (SMAD2). We identified two T?RI-interacting regions (TIRs) with opposing effects on TGF-? signaling. TIR1, located at the N terminus, inhibits canonical TGF-? signaling and promotes SMAD2 retention at T?RI, similar to full-length VEPH1. In contrast, TIR2, located at the C-terminal region encompassing the PH domain, decreases SMAD2 retention at T?RI and enhances TGF-? signaling. Our studies indicate that VEPH1 inhibits TGF-? signaling by impeding the release of activated SMAD2 from T?RI and may modulate TGF-? signaling during development and cancer initiation or progression. Twit Text FOAVip Human ortholog of Drosophila Melted impedes SMAD2 release from TGF- receptor I to inhibit TGF- signaling ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26039994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26039994 #FOAvip English Wikipedia <ref>{{Cite pmid|26039994 }}</ref> Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-? receptor I to inhibit TGF-? signaling #MMPMID26039994 Shathasivam P ; Kollara A ; Ringuette MJ ; Virtanen C ; Wrana JL ; Brown TJ Proc Natl Acad Sci U S A 2015[Jun]; 112 (23 ): E3000-9 PMID26039994 show ga Drosophila melted encodes a pleckstrin homology (PH) domain-containing protein that enables normal tissue growth, metabolism, and photoreceptor differentiation by modulating Forkhead box O (FOXO), target of rapamycin, and Hippo signaling pathways. Ventricular zone expressed PH domain-containing 1 (VEPH1) is the mammalian ortholog of melted, and although it exhibits tissue-restricted expression during mouse development and is potentially amplified in several human cancers, little is known of its function. Here we explore the impact of VEPH1 expression in ovarian cancer cells by gene-expression profiling. In cells with elevated VEPH1 expression, transcriptional programs associated with metabolism and FOXO and Hippo signaling were affected, analogous to what has been reported for Melted. We also observed altered regulation of multiple transforming growth factor-? (TGF-?) target genes. Global profiling revealed that elevated VEPH1 expression suppressed TGF-?-induced transcriptional responses. This inhibitory effect was verified on selected TGF-? target genes and by reporter gene assays in multiple cell lines. We further demonstrated that VEPH1 interacts with TGF-? receptor I (T?RI) and inhibits nuclear accumulation of activated Sma- and Mad-related protein 2 (SMAD2). We identified two T?RI-interacting regions (TIRs) with opposing effects on TGF-? signaling. TIR1, located at the N terminus, inhibits canonical TGF-? signaling and promotes SMAD2 retention at T?RI, similar to full-length VEPH1. In contrast, TIR2, located at the C-terminal region encompassing the PH domain, decreases SMAD2 retention at T?RI and enhances TGF-? signaling. Our studies indicate that VEPH1 inhibits TGF-? signaling by impeding the release of activated SMAD2 from T?RI and may modulate TGF-? signaling during development and cancer initiation or progression. |*Signal Transduction [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Nucleus/metabolism [MESH] |Drosophila [MESH] |Drosophila Proteins/*physiology [MESH] |Female [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/*physiology [MESH] |Ovarian Neoplasms/metabolism/pathology [MESH] |Receptors, Transforming Growth Factor beta/*metabolism [MESH] |Smad2 Protein/*metabolism [MESH]Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-? r(epmc).pdf DeepDyve Pubget Overpricing