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10.1073/pnas.1505924112 http://scihub22266oqcxt.onion/10.1073/pnas.1505924112 C4466702!4466702!26039988     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (23): 7237-42 Nephropedia Template TP {{tp|p=26039988|t=2015. pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205 |pdf=|usr=}}{{26039988}} gab.com Text pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205 JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26039988 #FOAvip Dendritic cells are critical in regulating immune responses. DEC205 (CD205) is an endocytotic receptor on dendritic cells with antigen presentation function and has been widely used in immune therapies. Here, we report that DEC205 is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism. The ectodomain of DEC205 forms a double-ringed conformation at acidic pH and becomes extended at basic pH. DEC205 only recognizes apoptotic and necrotic cells at acidic conditions with its N-terminal small ring and has no binding activities to healthy cells at either acidic or basic conditions, thus representing a novel pathway for immune clearance of dead cells and a potential mechanism for tumor scavenging. Twit Text FOAVip pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205 ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26039988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26039988 #FOAvip English Wikipedia <ref>{{Cite pmid|26039988}}</ref> pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205 #MMPMID26039988 Cao L; Shi X; Chang H; Zhang Q; He Y Proc Natl Acad Sci U S A 2015[Jun]; 112 (23): 7237-42 PMID26039988show ga Dendritic cells are critical in regulating immune responses. DEC205 (CD205) is an endocytotic receptor on dendritic cells with antigen presentation function and has been widely used in immune therapies. Here, we report that DEC205 is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism. The ectodomain of DEC205 forms a double-ringed conformation at acidic pH and becomes extended at basic pH. DEC205 only recognizes apoptotic and necrotic cells at acidic conditions with its N-terminal small ring and has no binding activities to healthy cells at either acidic or basic conditions, thus representing a novel pathway for immune clearance of dead cells and a potential mechanism for tumor scavenging. äpH-dependent recognition of apoptotic and necrotic cells by the human (epmc).pdf DeepDyve Pubget Overpricing