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10.1073/pnas.1505924112 http://scihub22266oqcxt.onion/10.1073/pnas.1505924112 C4466702!4466702 !26039988     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26039988 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (23 ): 7237-42 Nephropedia Template TP {{tp|p=26039988 |t=2015. pH-Dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205 |pdf=|usr=}}{{26039988 }} gab.com Text pH-Dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205 JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26039988 #FOAvip Dendritic cells play important roles in regulating innate and adaptive immune responses. DEC205 (CD205) is one of the major endocytotic receptors on dendritic cells and has been widely used for vaccine generation against viruses and tumors. However, little is known about its structure and functional mechanism. Here we determine the structure of the human DEC205 ectodomain by cryoelectron microscopy. The structure shows that the 12 extracellular domains form a compact double ring-shaped conformation at acidic pH and become extended at basic pH. Biochemical data indicate that the pH-dependent conformational change of DEC205 is correlated with ligand binding and release. DEC205 only binds to apoptotic and necrotic cells at acidic pH, whereas live cells cannot be recognized by DEC205 at either acidic or basic conditions. These results suggest that DEC205 is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism. Twit Text FOAVip pH-Dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205 ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26039988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26039988 #FOAvip English Wikipedia <ref>{{Cite pmid|26039988 }}</ref> pH-Dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205 #MMPMID26039988 Cao L ; Shi X ; Chang H ; Zhang Q ; He Y Proc Natl Acad Sci U S A 2015[Jun]; 112 (23 ): 7237-42 PMID26039988 show ga Dendritic cells play important roles in regulating innate and adaptive immune responses. DEC205 (CD205) is one of the major endocytotic receptors on dendritic cells and has been widely used for vaccine generation against viruses and tumors. However, little is known about its structure and functional mechanism. Here we determine the structure of the human DEC205 ectodomain by cryoelectron microscopy. The structure shows that the 12 extracellular domains form a compact double ring-shaped conformation at acidic pH and become extended at basic pH. Biochemical data indicate that the pH-dependent conformational change of DEC205 is correlated with ligand binding and release. DEC205 only binds to apoptotic and necrotic cells at acidic pH, whereas live cells cannot be recognized by DEC205 at either acidic or basic conditions. These results suggest that DEC205 is an immune receptor that recognizes apoptotic and necrotic cells specifically through a pH-dependent mechanism. |*Hydrogen-Ion Concentration [MESH] |Antigens, CD/chemistry/*physiology/ultrastructure [MESH] |Cryoelectron Microscopy [MESH] |Dendritic Cells/*cytology [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Lectins, C-Type/chemistry/*physiology/ultrastructure [MESH] |Minor Histocompatibility Antigens [MESH] |Mutagenesis [MESH] |Necrosis [MESH] |Protein Conformation [MESH]pH-Dependent recognition of apoptotic and necrotic cells by the human (epmc).pdf DeepDyve Pubget Overpricing