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10.7150/ijbs.12009 http://scihub22266oqcxt.onion/10.7150/ijbs.12009 C4466454!4466454!26078715     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Sci 2015 ; 11 (7): 726-36 Nephropedia Template TP {{tp|p=26078715|t=2015. Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming |pdf=|usr=}}{{26078715}} gab.com Text Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming JO: Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26078715 #FOAvip Ionizing radiation has a variety of acute and long-lasting adverse effects on the immune system. Whereas measureable effects of radiation on immune cell cytotoxicity and population change have been well studied in human and animal models, little is known about the functional alterations of the surviving immune cells after ionizing radiation. The objective of this study was to delineate the effects of radiation on T cell function by studying the alterations of T cell receptor activation and metabolic changes in activated T cells isolated from previously irradiated animals. Using a global metabolomics profiling approach, for the first time we demonstrate that ionizing radiation impairs metabolic reprogramming of T cell activation, which leads to substantial decreases in the efficiency of key metabolic processes required for activation, such as glucose uptake, glycolysis, and energy metabolism. In-depth understanding of how radiation impacts T cell function highlighting modulation of metabolism during activation is not only a novel approach to investigate the pivotal processes in the shift of T cell homeostasis after radiation, it also may lead to new targets for therapeutic manipulation in the combination of radiotherapy and immune therapy. Given that appreciable effects were observed with as low as 10 cGy, our results also have implications for low dose environmental exposures. Twit Text FOAVip Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming ????Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26078715 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26078715 #FOAvip English Wikipedia <ref>{{Cite pmid|26078715}}</ref> Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming #MMPMID26078715 Li HH; Wang Yw; Chen R; Zhou B; Ashwell JD; Fornace AJ Int J Biol Sci 2015[]; 11 (7): 726-36 PMID26078715show ga Ionizing radiation has a variety of acute and long-lasting adverse effects on the immune system. Whereas measureable effects of radiation on immune cell cytotoxicity and population change have been well studied in human and animal models, little is known about the functional alterations of the surviving immune cells after ionizing radiation. The objective of this study was to delineate the effects of radiation on T cell function by studying the alterations of T cell receptor activation and metabolic changes in activated T cells isolated from previously irradiated animals. Using a global metabolomics profiling approach, for the first time we demonstrate that ionizing radiation impairs metabolic reprogramming of T cell activation, which leads to substantial decreases in the efficiency of key metabolic processes required for activation, such as glucose uptake, glycolysis, and energy metabolism. In-depth understanding of how radiation impacts T cell function highlighting modulation of metabolism during activation is not only a novel approach to investigate the pivotal processes in the shift of T cell homeostasis after radiation, it also may lead to new targets for therapeutic manipulation in the combination of radiotherapy and immune therapy. Given that appreciable effects were observed with as low as 10 cGy, our results also have implications for low dose environmental exposures. äIonizing Radiation Impairs T Cell Activation by Affecting Metabolic Re(epmc).pdf DeepDyve Pubget Overpricing