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2015 ; 9
(ä): 90
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gab.com Text
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English Wikipedia
Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and
hunger: interactions between homeostatic and reward circuitry
#MMPMID26124708
Castro DC
; Cole SL
; Berridge KC
Front Syst Neurosci
2015[]; 9
(ä): 90
PMID26124708
show ga
The study of the neural bases of eating behavior, hunger, and reward has
consistently implicated the lateral hypothalamus (LH) and its interactions with
mesocorticolimbic circuitry, such as mesolimbic dopamine projections to nucleus
accumbens (NAc) and ventral pallidum (VP), in controlling motivation to eat. The
NAc and VP play special roles in mediating the hedonic impact ("liking") and
motivational incentive salience ("wanting") of food rewards, and their
interactions with LH help permit regulatory hunger/satiety modulation of food
motivation and reward. Here, we review some progress that has been made regarding
this circuitry and its functions: the identification of localized anatomical
hedonic hotspots within NAc and VP for enhancing hedonic impact; interactions of
NAc/VP hedonic hotspots with specific LH signals such as orexin; an
anterior-posterior gradient of sites in NAc shell for producing intense
appetitive eating vs. intense fearful reactions; and anatomically distributed
appetitive functions of dopamine and mu opioid signals in NAc shell and related
structures. Such findings help improve our understanding of NAc, VP, and LH
interactions in mediating affective and motivation functions, including "liking"
and "wanting" for food rewards.